Results
Title

Bioactive Cytochalasins from Aspergillus flavipes, an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius.

Authors

ZhenJian Lin; GuoJian Zhang; TianJiao Zhu; Rui Liu; HongJuan Wei; QianQun Gu

Abstract

Five new cytochalasins, Z16–Z201–5, and three known ones, 6–8, were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius.Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z172 and rosellichalasin 8 showed cytotoxic activities against A549 cell lines with IC50values of 5.6 and 7.9μM, respectively.

Subjects

CYTOCHALASINS; BIOACTIVE compounds; ASPERGILLUS; ENDOPHYTIC fungi; MANGROVE plants; ACANTHUS; SPECTRUM analysis; ANTINEOPLASTIC agents

Publication

Helvetica Chimica Acta, 2009, Vol 92, Issue 8, p1538

ISSN

0018-019X

Publication type

Academic Journal

DOI

10.1002/hlca.200800455