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- Title
Bioactive Cytochalasins from Aspergillus flavipes, an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius.
- Authors
ZhenJian Lin; GuoJian Zhang; TianJiao Zhu; Rui Liu; HongJuan Wei; QianQun Gu
- Abstract
Five new cytochalasins, Z16–Z201–5, and three known ones, 6–8, were isolated from Aspergillus flavipes, an endophytic fungus associated with Acanthus ilicifolius.Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z172 and rosellichalasin 8 showed cytotoxic activities against A549 cell lines with IC50values of 5.6 and 7.9μM, respectively.
- Subjects
CYTOCHALASINS; BIOACTIVE compounds; ASPERGILLUS; ENDOPHYTIC fungi; MANGROVE plants; ACANTHUS; SPECTRUM analysis; ANTINEOPLASTIC agents
- Publication
Helvetica Chimica Acta, 2009, Vol 92, Issue 8, p1538
- ISSN
0018-019X
- Publication type
Academic Journal
- DOI
10.1002/hlca.200800455