Synthesis of Vitamin B¹² Derivatives with a Peripheral Metal Binding Site.

Mayor, Marcel; Scheffold, Rolf; Walder, Lorenz

The synthesis and structural characterization of the vitamin B12 derivatives 9 and 10 equipped with a peripheral EDTA (ethylenediaminetetraacetic acid) binding site is described. It is based on the condensation of an activated ester of cobester- c-acid with ethane-1,2-diamine or 2-aminoethanol followed by acylation of the resulting amines with the monoanhydride 8 of EDTA. The title compounds 9 and 10 can be used as modifiers for metal oxide semiconductor electrodes and are potential precursors for the synthesis of bimetallic, supramolecular catalysts.

Helvetica Chimica Acta, 1997, Vol 80, Issue 4, p1183

0018-019X

Academic Journal

10.1002/hlca.19970800416