Reduktive Co-Alkylierung von Heptamethyl-cobyrinat mit dem Methylthiomalonat ( S)-Methyl-3-bromo-2-[(ethylthio) carbonyl]-2-methylpropanoat.

Müller, Susanna; Wolleb, Annemarie; Walder, Lorenz; Keese, Reinhart

Reductive Co Alkylation of Heptamethyl Cobyrinate with the Methylthiomalonate ( S)-Methyl 3-Bromo-2-[(ethylthio)carbonyl]-2-methylpropanoate The methylthiomalonate(−)-( S)-Methyl 3-bromo-2-[(ethylthio)carbonyl]-2-methylpropanoate( 5a)was prepared from dimethyl methylmalonate in five steps via the stereospecific cleavage of the ( pro- S)-ester group of 1 with pig-liver esterase in an overall yield of 26.5% ( Scheme 4a). Reductive Co alkylation of heptamethyl Coβ-perchlorato cob (II)yrinate ( 8) with 5a by electrosynthesis lead to the alkylcobalt complex 9a in 40% yield ( Scheme 4b). The O2-dependent reactions of the methyhnalonyl fragment produced by photolysis of 9a and its deuterated derivative 9c are reported ( Scheme 5).

Helvetica Chimica Acta, 1990, Vol 73, Issue 6, p1659

0018-019X

Academic Journal

10.1002/hlca.19900730611