Exploring the Impact of Dietary Factors on Intestinal Diverticular Disease: A Mendelian Randomization Approach.

Tian, Wangzhao; Yang, Wenwen; Wang, Xiaorui; Yang, Yanjiang

Dietary habits significantly influence the development of intestinal diverticular disease (IDD), a common gastrointestinal condition primarily affecting the colon. We performed a Mendelian randomization (MR) analysis on 20 diet‐related factors using data from the UK Biobank. IDD cases (n = 33,618) and controls (n = 329,381) were obtained from the FinnGen Biobank. Three key MR methods were applied: the inverse‐variance‐weighted (IVW) method as the primary approach to estimate causal relationships, along with the weighted median (WM) and MR‐Egger methods. Significant associations were found for pork intake (β = 1.06, p = 0.00244), nonoily fish intake (β = 0.709, p = 0.0449), oily fish intake (β = 0.246, p = 0.0222), and dried fruit intake (β = −0.953, p < 0.0001). After false discovery rate (FDR) adjustment, pork intake (q = 0.0244) and dried fruit intake (q < 0.0001) remained significant. Our results indicate that while pork and certain types of fish intake may elevate the risk of IDD, dried fruit intake may offer a protective effect. These findings highlight the potential of dietary changes in IDD prevention and management, though further research across diverse populations is needed.

MENDELIAN randomization; DIVERTICULOSIS; DIETARY patterns; INTESTINAL diseases; DRIED fruit

Food Science & Nutrition, 2024, Vol 12, Issue 12, p10859

2048-7177

Academic Journal

10.1002/fsn3.4623