Results
Title

One‐Pot Synthesis of Thioamides via Nickel‐Catalyzed Coupling of Thiocarbamoyl Fluorides and Boronic Acids.

Authors

Mumtaz, Yasir; Xiang, Haonan; Khan, Jahangir; Liang, Shuaishuai; Yi, Wenbin

Abstract

A novel and efficient one‐pot method has been developed for the synthesis of thioamides through coupling reactions between thiocarbamoyl fluorides, which are generated in situ from amines, and boronic acids. The key to the success of this transformation lies in the use of nickel a catalyst combined with PCy3 as a ligand. This innovative reaction protocol provides mild reaction conditions suitable for producing a diverse array of thioamides, and the late‐stage modification of amoxapine was successfully achieved.

Subjects

COUPLING reactions (Chemistry); NICKEL catalysts; LIGANDS (Chemistry); THIOAMIDES; FLUORIDES; BORONIC acids; AMINES

Publication

European Journal of Organic Chemistry, 2024, Vol 27, Issue 45, p1

ISSN

1434-193X

Publication type

Academic Journal

DOI

10.1002/ejoc.202400742