An Efficient Synthesis of Benzyl Dithiocarbamates by Base‐Promoted Cross‐Coupling Reactions of Benzyl Chlorides with Tetraalkylthiuram Disulfides at Room Temperature.

Wu, Zhiyong; Lai, Miao; Zhang, Siyuan; Zhong, Xianyun; Song, Hao; Zhao, Mingqin

A straightforward, mild and efficient protocol for the synthesis of benzyl dithiocarbamates from benzyl chlorides and tetraalkylthiuram disulfides is presented. This protocol is compatible with a wide variety of electron‐donating and ‐withdrawing substituents and enables construction of various dithiocarbamate derivatives from readily available starting materials. A mild and efficient synthesis of benzyl dithiocarbamates through transition metal free cross‐coupling reactions was developed. This attractive methodology for the synthesis of benzyl dithiocarbamate derivatives is of great significance due to the potential utilization of the product in pharmaceutical industry.

DITHIOCARBAMATES; BENZYL chloride; COUPLING reactions (Chemistry); DISULFIDES; TEMPERATURE effect; TRANSITION metals

European Journal of Organic Chemistry, 2018, Vol 2018, Issue 48, p7033

1434-193X

Academic Journal

10.1002/ejoc.201801449