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- Title
Asymmetric Michael Reaction of Aldehydes and Dicyanoalkenes Catalyzed by Diphenylprolinol Silyl Ether.
- Authors
Hayashi, Yujiro; Kranidiotis‐Hisatomi, Nektarios; Sakamoto, Daisuke; Oritani, Kyohei; Kawamoto, Takuji; Kamimura, Akio
- Abstract
Asymmetric Michael reactions of aldehydes and dicyanoalkenes catalyzed by diphenylprolinol silyl ether give the corresponding Michael adducts in good yields with excellent enantioselectivities. The diastereoselectivity is dependent on the bulkiness of the Michael donor. The Michael adducts can be easily transformed into useful chiral compounds such as lactones, esters, and monocyanated derivatives. Asymmetric Michael reaction of aldehydes and dicyanoalkenes catalyzed by diphenylprolinol silyl ether gives the corresponding Michael adducts in good yields with excellent enantioselectivities. The Michael adducts can be easily transformed into useful chiral compounds such as lactones, esters and monocyanated derivatives.
- Subjects
ALDEHYDES; MICHAEL reaction; ALKENES; SILYL ethers; ENANTIOSELECTIVE catalysis; CHEMICAL yield
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 48, p6843
- ISSN
1434-193X
- Publication type
Academic Journal
- DOI
10.1002/ejoc.201800831