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Title: Domino Reactions of Chromone-3-carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2,3-c]coumarins and their Optical and Biological Activity.
Authors: Miliutina, Mariia; Janke, Julia; Chirkina, Elena; Hassan, Sidra; Ejaz, Syeda Abida; Khan, Shafi Ullah; Iqbal, Jamshed; Friedrich, Aleksej; Lochbrunner, Stefan; Ivanov, Anton; Villinger, Alexander; Lecka, Joanna; Sévigny, Jean; Langer, Peter
Abstract: A series of new heteroannulated pyrido[2,3-c]coumarins have been prepared by the domino reactions of chromone-3-carboxylic acid derivatives with electron-rich binucleophilic aminoheterocycles. The products contain the core structures of coumarin, pyridine, and an annulated five-membered heterocyclic system, namely pyrazole, pyrrole, or isoazole. The fluorescence of the products was investigated. The products inhibit ecto-5′-nucleotidase (e5′NT) enzymatic activity.
Subjects: CARBOXYLIC acid derivatives; HETEROCYCLIC compounds synthesis; COUMARINS; PYRIDINE; FLUORESCENCE
Publication: European Journal of Organic Chemistry, 2017, Vol 2017, Issue 47, p7148
ISSN: 1434-193X
Publication type: Academic Journal
DOI: 10.1002/ejoc.201701276

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Domino Reactions of Chromone-3-carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2,3-c]coumarins and their Optical and Biological Activity.