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- Title
Catalytic Asymmetric Addition of Organolithium Reagents to Aldehydes.
- Authors
Veguillas, Marcos; Solà, Ricard; Shaw, Luke; Maciá, Beatriz
- Abstract
Herein we report an efficient catalytic system for the titanium-promoted enantioselective addition of organolithium reagents to aldehydes, based on chiral Ar-BINMOL ligands. Unprecedented yields and enantioselectivities are achieved in the alkylation reactions of aliphatic aldehydes. Remarkably, methyllithium can be added to a wide variety of aromatic and aliphatic aldehydes, providing versatile chiral methyl carbinol units in a simple one-pot procedure under mild conditions and in very short reaction times.
- Subjects
ORGANOLITHIUM compounds; ALDEHYDES; TITANIUM catalysts; CATALYSIS; ALKYLATION; METHYLLITHIUM
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 9, p1788
- ISSN
1434-193X
- Publication type
Academic Journal
- DOI
10.1002/ejoc.201600104