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- Title
Evaluation and Elucidation of DNA-Containing Viologen Dendrimer Complex Formation.
- Authors
Bongard, Dirk; Degefa, Tesfaye Hailu; Schön, Peter; Giese, Maria; Brandt, Roland; Walder, LorENz
- Abstract
The syntheses of a tetracationic viologen and polycationic viologen dendrimers are described in this report. These water-soluble viologen dendrimers, the tetracationic viologen, and their DNA-containing complexes have been investigated by cyclic voltammetry (CV), electrophoresis, and atomic force microscopy with respect to their stability and effectiveness as possible transfection systems. The appearance of a negative potential shift and the loss of current in the cyclovoltammograms of viologen dendriplexes have been attributed to DNA/dendrimer complex formation. Oligomers of viologen with at least 4 positive charges are required for the formation of a primary DNA-viologen complex. The dynamics of the formation of a secondary complex was observed and studied by cyclic voltammetry. AFM measurements together with molecular modeling support the electrochemical results and show two different aggregates of the dendriplexes on gold.
- Subjects
VIOLOGENS; DENDRIMERS; ORGANIC synthesis research; OLIGOMERS; CYCLIC voltammetry; ELECTROPHORESIS
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 10, p1897
- ISSN
1434-193X
- Publication type
Academic Journal
- DOI
10.1002/ejoc.201501485