Greener Paal-Knorr Pyrrole Synthesis by Mechanical Activation.

Akelis, Liudvikas; Rousseau, Jolanta; Juskenas, Robertas; Dodonova, Jelena; Rousseau, Cyril; Menuel, Stéphane; Prevost, Dominique; Tumkevičius, Sigitas; Monflier, Eric; Hapiot, Frédéric

A straightforward and solventless synthesis of pyrroles was developed by using mechanochemical activation and a biosourced organic acid as the catalyst. Relative to traditional Paal-Knorr methodologies, various N-substituted pyrroles were obtained in very short reaction times. By reaction with unreactive diketones, desymmetrized aliphatic and aromatic compounds were also synthesized.

CHEMICAL synthesis; PYRROLES; ORGANIC acids; CATALYSTS; ALIPHATIC compounds; KETONES

European Journal of Organic Chemistry, 2016, Vol 2016, Issue 1, p31

1434-193X

Academic Journal

10.1002/ejoc.201501223