Title: First Catalyzed Hydration of Haloalkynes by a Recyclable Catalytic System.
Authors: Zou, Huaxu; He, Weibao; Dong, Qizhi; Wang, Ruijia; Yi, Niannian; Jiang, Jun; Pen, Dongming; He, Weimin
Abstract: The hydration of haloalkynes to give α-halomethyl ketones was achieved based on a combination of a Cu(OAc)2 catalyst and a TFA (trifluoroacetic acid) promoter. This is the first synthesis of chloro/bromo/iodo methyl ketones through a hydration reaction catalyzed by a recyclable catalytic system. The catalytic system has a wide substrate scope and excellent chemoselectivity, and the procedure can also be scaled up.
Subjects: ALKYNE synthesis; KETONES; COPPER compounds synthesis; CATALYSIS synthesis; CHEMOSELECTIVITY
Publication: European Journal of Organic Chemistry, 2016, Vol 2016, Issue 1, p116
ISSN: 1434-193X
Publication type: Academic Journal
DOI: 10.1002/ejoc.201501198

First Catalyzed Hydration of Halo­alkynes by a Recyclable Catalytic ­System.

Zou, Huaxu; He, Weibao; Dong, Qizhi; Wang, Ruijia; Yi, Niannian; Jiang, Jun; Pen, Dongming; He, Weimin