Title: A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction.
Authors: Iminov, Rustam T.; Mashkov, Alexander V.; Chalyk, Bohdan A.; Mykhailiuk, Pavel K.; Tverdokhlebov, Anton V.; Tolmachev, Andrey A.; Volovenko, Yulian M.; Shishkin, Oleg V.; Shishkina, Svetlana V.
Abstract: The reaction of ethyl 3-(alkylamino)-4,4,4-trifluoro-but-2-enoates with mesyl azide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) gave ethyl 1-alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylates in good yields. Further hydrolysis of the ester group afforded the title compounds on a multigram scale.
Publication: European Journal of Organic Chemistry, 2013, Vol 2013, Issue 14, p2891
ISSN: 1434-193X
Publication type: Academic Journal
DOI: 10.1002/ejoc.201300030

A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction.

Iminov, Rustam T.; Mashkov, Alexander V.; Chalyk, Bohdan A.; Mykhailiuk, Pavel K.; Tverdokhlebov, Anton V.; Tolmachev, Andrey A.; Volovenko, Yulian M.; Shishkin, Oleg V.; Shishkina, Svetlana V.