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- Title
Acetamide as Cocatalyst for the Nitrogen-Directed Coupling of Arenes with Aryl Chlorides through Ruthenium-Catalyzed C-H Activation.
- Authors
Zhang, Jie; Yang, Qin; Zhu, Zhu; Yuan, Mao Lin; Fu, Hai Yan; Zheng, Xue Li; Chen, Hua; Li, Rui Xiang
- Abstract
A simple and highly efficient method for the cross-coupling of aromatics by C-H activation is described. Acetamide was found to be an effective cocatalyst for this generally applicable ruthenium(II)-catalyzed direct arylation reaction. A wide range of deactivated aryl chlorides could be efficiently coupled under the mild temperature of 101 °C. The new process is highly atom-economical and sustainable.
- Publication
European Journal of Organic Chemistry, 2012, Vol 2012, Issue 34, p6702
- ISSN
1434-193X
- Publication type
Academic Journal
- DOI
10.1002/ejoc.201201127