Works matching AU Appendino, Giovanni

Results: 85

The Impact of a Quinone Scaffold on Thermo-TRPs Modulation by Dimethylheptyl Phytocannabinoids.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 6, p. 2682, doi. 10.3390/ijms26062682

By:

Schiano Moriello, Aniello;
Bossoni, Aurora;
Mattoteia, Daiana;
Caprioglio, Diego;
Minassi, Alberto;
Appendino, Giovanni;
De Petrocellis, Luciano;
Amodeo, Pietro;
Vitale, Rosa Maria

Publication type:

Article

Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge‐Prey Chelonaplysilla sp.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 21, p. 1, doi. 10.1002/chem.202203858

By:

Shen, Shou‐Mao;
Li, Song‐Wei;
Su, Ming‐Zhi;
Yao, Li‐Gong;
Appendino, Giovanni;
Guo, Yue‐Wei

Publication type:

Article

Molecular diversity and natural products.

Published in:

2011

By:

Appendino, Giovanni;
Banfi, Luca

Publication type:

Editorial

The transient receptor potential channel TRPA1: from gene to pathophysiology.

Published in:

Pflügers Archiv: European Journal of Physiology, 2012, v. 464, n. 5, p. 425, doi. 10.1007/s00424-012-1158-z

By:

Nilius, Bernd;
Appendino, Giovanni;
Owsianik, Grzegorz

Publication type:

Article

Ligustilide: a novel TRPA1 modulator.

Published in:

Pflügers Archiv: European Journal of Physiology, 2011, v. 462, n. 6, p. 841, doi. 10.1007/s00424-011-1021-7

By:

Zhong, Jian;
Pollastro, Federica;
Prenen, Jean;
Zhu, Zhiming;
Appendino, Giovanni;
Nilius, Bernd

Publication type:

Article

Umbellulone modulates TRP channels.

Published in:

Pflügers Archiv: European Journal of Physiology, 2011, v. 462, n. 6, p. 861, doi. 10.1007/s00424-011-1043-1

By:

Zhong, Jian;
Minassi, Alberto;
Prenen, Jean;
Taglialatela-Scafati, Orazio;
Appendino, Giovanni;
Nilius, Bernd

Publication type:

Article

Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 8, p. 1084, doi. 10.3390/biom12081084

By:

Caprioglio, Diego;
Amin, Hawraz Ibrahim M.;
Taglialatela-Scafati, Orazio;
Muñoz, Eduardo;
Appendino, Giovanni

Publication type:

Article

Cannabidiol (CBD) From Non-Cannabis Plants: Myth or Reality?

Published in:

Natural Product Communications, 2022, v. 17, n. 5, p. 1, doi. 10.1177/1934578X221098843

By:

Appendino, Giovanni;
Taglialatela-Scafati, Orazio;
Muñoz, Eduardo

Publication type:

Article

Efficacy and Safety of Meriva®, a Curcumin-phosphatidylcholine Complex, during Extended Administration in Osteoarthritis Patients.

Published in:

Alternative Medicine Review, 2010, v. 15, n. 4, p. 337

By:

Belcaro, Gianni;
Cesarone, Maria Rosaria;
Dugall, Mark;
Pellegrini, Luciano;
Ledda, Andrea;
Grossi, Maria Giovanna;
Togni, Stefano;
Appendino, Giovanni

Publication type:

Article

Omnia praeclara rara. Die Ingenol-Forschung kommt in Fahrt.

Published in:

Angewandte Chemie, 2014, v. 126, n. 4, p. 943, doi. 10.1002/ange.201308281

By:

Appendino, Giovanni

Publication type:

Article

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Published in:

Angewandte Chemie, 2011, v. 123, n. 2, p. 487, doi. 10.1002/ange.201005959

By:

Avonto, Cristina;
Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Di Marzo, Vincenzo;
De Petrocellis, Luciano;
Appendino, Giovanni

Publication type:

Article

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34259-0

By:

Palomares, Belen;
Ruiz-Pino, Francisco;
Navarrete, Carmen;
Velasco, Inmaculada;
Sánchez-Garrido, Miguel A.;
Jimenez-Jimenez, Carla;
Pavicic, Carolina;
Vazquez, Maria J.;
Appendino, Giovanni;
Bellido, M. Luz;
Calzado, Marco A.;
Tena-Sempere, Manuel;
Muñoz, Eduardo

Publication type:

Article

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.

Published in:

2018

By:

del Rio, Carmen;
Cantarero, Irene;
Palomares, Belén;
Gómez‐Cañas, María;
Fernández‐Ruiz, Javier;
Pavicic, Carolina;
García‐Martín, Adela;
Luz Bellido, Maria;
Ortega‐Castro, Rafaela;
Pérez‐Sánchez, Carlos;
López‐Pedrera, Chary;
Appendino, Giovanni;
Calzado, Marco A.;
Muñoz, Eduardo;
Gómez-Cañas, María;
Fernández-Ruiz, Javier;
García-Martín, Adela;
Ortega-Castro, Rafaela;
Pérez-Sánchez, Carlos;
López-Pedrera, Chary

Publication type:

journal article

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

Published in:

2017

By:

Nadal, Xavier;
Río, Carmen;
Casano, Salvatore;
Palomares, Belén;
Ferreiro‐Vera, Carlos;
Navarrete, Carmen;
Sánchez‐Carnerero, Carolina;
Cantarero, Irene;
Bellido, Maria Luz;
Meyer, Stefan;
Morello, Gaetano;
Appendino, Giovanni;
Muñoz, Eduardo;
Del Río, Carmen;
Palomares, Belén;
Ferreiro-Vera, Carlos;
Sánchez-Carnerero, Carolina;
Muñoz, Eduardo

Publication type:

journal article

The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.

Published in:

2017

By:

Benemei, Silvia;
De Logu, Francesco;
Li Puma, Simone;
Marone, Ilaria Maddalena;
Coppi, Elisabetta;
Ugolini, Filippo;
Liedtke, Wolfgang;
Pollastro, Federica;
Appendino, Giovanni;
Geppetti, Pierangelo;
Materazzi, Serena;
Nassini, Romina

Publication type:

journal article

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 10, p. 2608, doi. 10.1111/bph.12320

By:

De Petrocellis, Luciano;
Schiano Moriello, Aniello;
Fontana, Gabriele;
Sacchetti, Alessandro;
Passarella, Daniele;
Appendino, Giovanni;
Di Marzo, Vincenzo

Publication type:

Article

Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons.

Published in:

2010

By:

Wyrembek, Paulina;
Lebida, Katarzyna;
Mercik, Katarzyna;
Szczuraszek, Katarzyna;
Szczot, Marcin;
Pollastro, Federica;
Appendino, Giovanni;
Mozrzymas, Jerzy W

Publication type:

journal article

IODINATION OF PARACETAMOL.

Published in:

Journal of Advanced Scientific Research, 2014, v. 5, n. 1, p. 37

By:

Abdellah, Ech-chahad;
Lahboub, Bouyazza;
Appendino, Giovanni

Publication type:

Article

Synthesis and Biological Evaluation of PaclitaxelThiocolchicine Hybrids.

Published in:

Chemistry & Biodiversity, 2004, v. 1, n. 2, p. 327, doi. 10.1002/cbdv.200490029

By:

Danieli, Bruno;
Giardini, Alessandra;
Lesma, Giordano;
Passarella, Daniele;
Silvani, Alessandra;
Appendino, Giovanni;
Noncovich, Alain;
Fontana, Gabriele;
Bombardelli, Ezio;
Sterner, Olov

Publication type:

Article

Oxidative Fragmentation of the Bridged β-Triketone Core of Hyperforin.

Published in:

European Journal of Organic Chemistry, 2004, v. 2004, n. 6, p. 1193, doi. 10.1002/ejoc.200300568

By:

Luisella Verotta;
Erminio Lovaglio;
Olov Sterner;
Giovanni Appendino;
Ezio Bombardelli

Publication type:

Article

Cover Picture: Oxidative Fragmentation of the Bridged β-Triketone Core of Hyperforin (Eur. J. Org. Chem. 6/2004).

Published in:

European Journal of Organic Chemistry, 2004, v. 2004, n. 6, p. 1165, doi. 10.1002/ejoc.200490012

By:

Luisella Verotta;
Erminio Lovaglio;
Olov Sterner;
Giovanni Appendino;
Ezio Bombardelli

Publication type:

Article

The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids.

Published in:

European Journal of Organic Chemistry, 2003, v. 2003, n. 22, p. 4422, doi. 10.1002/ejoc.200300376

By:

Giovanni Appendino;
Alain Noncovich;
Piergiorgio Bettoni;
Paolo Dambruoso;
Olov Sterner;
Gabriele Fontana;
Ezio Bombardelli

Publication type:

Article

Synthesis of Modified Ingenol Esters.

Published in:

European Journal of Organic Chemistry, 1999, v. 1999, n. 12, p. 3413, doi. 10.1002/(SICI)1099-0690(199912)1999:12<3413::AID-EJOC3413>3.0.CO;2-S

By:

Appendino, Giovanni;
Tron, Gian Cesare;
Cravotto, Giancarlo;
Palmisano, Giovanni;
Annunziata, Rita;
Baj, Germano;
Surico, Nicola

Publication type:

Article

A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis.

Published in:

Journal of NeuroImmune Pharmacology, 2012, v. 7, n. 4, p. 1002, doi. 10.1007/s11481-012-9399-3

By:

Granja, Aitor;
Carrillo-Salinas, Francisco;
Pagani, Alberto;
Gómez-Cañas, María;
Negri, Roberto;
Navarrete, Carmen;
Mecha, Miriam;
Mestre, Leyre;
Fiebich, Bend;
Cantarero, Irene;
Calzado, Marco;
Bellido, Maria;
Fernandez-Ruiz, Javier;
Appendino, Giovanni;
Guaza, Carmen;
Muñoz, Eduardo

Publication type:

Article

Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 6, p. 978, doi. 10.1038/jcbfm.2012.36

By:

Muzzi, Mirko;
Felici, Roberta;
Cavone, Leonardo;
Gerace, Elisabetta;
Minassi, Alberto;
Appendino, Giovanni;
Moroni, Flavio;
Chiarugi, Alberto

Publication type:

Article

The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 1070, doi. 10.3390/biomedicines9081070

By:

Mattoteia, Daiana;
Schiano Moriello, Aniello;
Taglialatela-Scafati, Orazio;
Amodeo, Pietro;
De Petrocellis, Luciano;
Appendino, Giovanni;
Vitale, Rosa Maria;
Caprioglio, Diego

Publication type:

Article

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 2, p. 467, doi. 10.1002/anie.201005959

By:

Avonto, Cristina;
Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Di Marzo, Vincenzo;
De Petrocellis, Luciano;
Appendino, Giovanni

Publication type:

Article

The 1,2,3-Triazole Ring as a Peptido- and Olefinomimetic Element: Discovery of Click Vanilloids and Cannabinoids.

Published in:

Angewandte Chemie International Edition, 2007, v. 46, n. 48, p. 9312, doi. 10.1002/anie.200703590

By:

Appendino, Giovanni;
Bacchiega, Sara;
Minassi, Alberto;
Cascio, Maria Grazia;
De Petrocellis, Luciano;
Di Marzo, Vincenzo

Publication type:

Article

Biological properties of jatrophane polyesters, new microtubule-interacting agents.

Published in:

Cancer Chemotherapy & Pharmacology, 2003, v. 51, n. 1, p. 67, doi. 10.1007/s00280-002-0541-4

By:

Miglietta, Antonella;
Gabriel, Ludovica;
Appendino, Giovanni;
Bocca, Claudia

Publication type:

Article

Comparative Evaluation of Anticancer Activity of Natural Methoxylated Flavones Xanthomicrol and Eupatilin in A375 Skin Melanoma Cells.

Published in:

Life (2075-1729), 2024, v. 14, n. 3, p. 304, doi. 10.3390/life14030304

By:

Rosa, Antonella;
Piras, Franca;
Pollastro, Federica;
Sogos, Valeria;
Appendino, Giovanni;
Nieddu, Mariella

Publication type:

Article

Non-pungent capsaicinoids from sweet pepper: Synthesis and evaluation of the chemopreventive and anticancer potential.

Published in:

European Journal of Nutrition, 2003, v. 42, n. 1, p. 2, doi. 10.1007/s00394-003-0394-6

By:

Macho, Antonio;
Lucena, Concepción;
Sancho, Rocio;
Daddario, Nives;
Minassi, Alberto;
Muñoz, Eduardo;
Appendino, Giovanni

Publication type:

Article

Bioactive Phloroglucinyl Heterodimers: The Tautomeric and Rotameric Equlibria of Arzanol.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 28, p. 4810, doi. 10.1002/ejoc.201600597

By:

Rastrelli, Federico;
Bagno, Alessandro;
Appendino, Giovanni;
Minassi, Alberto

Publication type:

Article

The Thia-Michael Reactivity of Zerumbone and Related Cross-Conjugated Dienones: Disentangling Stoichiometry, Regiochemistry, and Addition Mode with an NMR-Spectroscopy-Based Cysteamine Assay.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 17, p. 3721, doi. 10.1002/ejoc.201500237

By:

Appendino, Giovanni;
Minassi, Alberto;
Collado, Juan A.;
Pollastro, Federica;
Chianese, Giuseppina;
Taglialatela‐Scafati, Orazio;
Ayyari, Mehdi;
Garcia, Victor;
Muñoz, Eduardo

Publication type:

Article

Sesquiterpenoids from Common Ragweed ( Ambrosia artemisiifolia L.), an Invasive Biological Polluter.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 27, p. 5162, doi. 10.1002/ejoc.201200650

By:

Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Chianese, Giuseppina;
De Petrocellis, Luciano;
Di Marzo, Vincenzo;
Appendino, Giovanni

Publication type:

Article

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 4, p. 772, doi. 10.1002/ejoc.201101193

By:

Minassi, Alberto;
Cicione, Lavinia;
Koeberle, Andreas;
Bauer, Julia;
Laufer, Stefan;
Werz, Oliver;
Appendino, Giovanni

Publication type:

Article

Pietro Biginelli: The Man Behind the Reaction.

Published in:

European Journal of Organic Chemistry, 2011, v. 2011, n. 28, p. 5541, doi. 10.1002/ejoc.201100661

By:

Tron, Gian Cesare;
Minassi, Alberto;
Appendino, Giovanni

Publication type:

Article

Anionic and Photochemical Behaviour of the Medium-Sized Terpenoid Ketone 8-Dehydro-12-O-methyl-deacylhallerinDedicated to the memory of Anna Ramella PralungoAnd it seems to me you lived your life Like a candle in the wind (“Candle in the wind”, Elton John) We dedicate this paper to the memory of Anna, whose recent death at the tragically early age of 33 came as a profound shock to her friends and colleagues. Anna was a lively and engaging young woman, dynamic, generous and life-loving. She was a committed, hard-working student, when she undertook the research described in this paper, which constitutes the substance of her master’s thesis.

Published in:

European Journal of Organic Chemistry, 2006, v. 2006, n. 14, p. 3140, doi. 10.1002/ejoc.200600107

By:

Gianluca Croce;
Marco Milanesio;
Davide Viterbo;
Marco Clericuzio;
Piero Ugliengo;
Giovanni Appendino

Publication type:

Article

Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids.

Published in:

European Journal of Organic Chemistry, 2004, v. 2004, n. 16, p. 3413, doi. 10.1002/ejoc.200400122

By:

Giovanni Appendino;
Andrea Bertolino;
Alberto Minassi;
Rita Annunziata;
Arpad Szallasi;
Luciano de Petrocellis;
Vincenzo Di Marzo

Publication type:

Article

Cover Picture: Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids (Eur. J. Org. Chem. 16/2004).

Published in:

European Journal of Organic Chemistry, 2004, v. 2004, n. 16, p. 3367, doi. 10.1002/ejoc.200490032

By:

Giovanni Appendino;
Andrea Bertolino;
Alberto Minassi;
Rita Annunziata;
Arpad Szallasi;
Luciano de Petrocellis;
Vincenzo Di Marzo

Publication type:

Article

First “hybrid” ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

Published in:

FEBS Letters, 2006, v. 580, n. 2, p. 568, doi. 10.1016/j.febslet.2005.12.069

By:

Appendino, Giovanni;
Cascio, Maria Grazia;
Bacchiega, Sara;
Moriello, Aniello Schiano;
Minassi, Alberto;
Thomas, Adèle;
Ross, Ruth;
Pertwee, Roger;
De Petrocellis, Luciano;
Di Marzo, Vincenzo

Publication type:

Article

Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.

Published in:

Angewandte Chemie, 2017, v. 129, n. 27, p. 8043, doi. 10.1002/ange.201703455

By:

Minassi, Alberto;
Pollastro, Federica;
Chianese, Giuseppina;
Caprioglio, Diego;
Taglialatela‐Scafati, Orazio;
Appendino, Giovanni

Publication type:

Article

Selective analysis of phenolic compounds in propolis by HPLC-MS/MS.

Published in:

Phytochemical Analysis, 2008, v. 19, n. 1, p. 32, doi. 10.1002/pca.1010

By:

Medana, Claudio;
Carbone, Francesco;
Aigotti, Riccardo;
Appendino, Giovanni;
Baiocchi, Claudio

Publication type:

Article

HPLC-UV and HPLC-positive-ESI-MS analysis of the diterpenoid fraction from caper spurge ( Euphorbia lathyris) seed oil.

Published in:

Phytochemical Analysis, 2001, v. 12, n. 4, p. 255, doi. 10.1002/pca.592

By:

Bicchi, Carlo;
Appendino, Giovanni;
Cordero, Chiara;
Rubiolo, Patrizia;
Ortelli, Didier;
Veuthey, Jean-Luc

Publication type:

Article

Tasty and healthy TR(i)Ps. The human quest for culinary pungency.

Published in:

EMBO Reports, 2011, v. 12, n. 11, p. 1094, doi. 10.1038/embor.2011.200

By:

Nilius, Bernd;
Appendino, Giovanni

Publication type:

Article

Helichrysum italicum: THE SLEEPING GIANT OF MEDITERRANEAN HERBAL MEDICINE.

Published in:

HerbalGram, 2015, n. 105, p. 34

By:

Appendino, Giovanni;
Minassi, Alberto;
Pollastro, Federica;
Taglialatela-Scafati, Orazio;
Ballero, Mauro;
Maxia, Andrea;
Sanna, Cinzia

Publication type:

Article

Herbs and Healers from the Ancient Mediterranean through the Medieval West: Essays in Honor of John M. Riddle.

Published in:

2013

By:

Appendino, Giovanni

Publication type:

Book Review

Omnia praeclara rara. The Quest for Ingenol Heats Up.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 4, p. 927, doi. 10.1002/anie.201308281

By:

Appendino, Giovanni

Publication type:

Article

Oxidative Addition of 4-Hydroxycoumarin to Alkenes. An Expeditious Entry to 2,3-Dihydro-4 H -furo-[3,2- c ][1]benzopyran-4-ones.

Published in:

Synthetic Communications, 1996, v. 26, n. 18, p. 3359, doi. 10.1080/00397919608003739

By:

Appendino, Giovanni;
Cravotto, Giancarlo;
Palmisano, Giovanni;
Annunziata, Rita

Publication type:

Article

Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors.

Published in:

2020

By:

Palomares, Belén;
Garrido‐Rodriguez, Martín;
Gonzalo‐Consuegra, Claudia;
Gómez‐Cañas, María;
Saen‐oon, Suwipa;
Soliva, Robert;
Collado, Juan A.;
Fernández‐Ruiz, Javier;
Morello, Gaetano;
Calzado, Marco A.;
Appendino, Giovanni;
Muñoz, Eduardo;
Garrido-Rodriguez, Martín;
Gonzalo-Consuegra, Claudia;
Gómez-Cañas, María;
Saen-Oon, Suwipa;
Fernández-Ruiz, Javier

Publication type:

journal article

Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-κB activation and is a potent antiinflammatory compound in vivo.

Published in:

European Journal of Immunology, 2002, v. 32, n. 6, p. 1753, doi. 10.1002/1521-4141(200206)32:6<1753::AID-IMMU1753>3.0.CO;2-2

By:

Sancho, Rocío;
Lucena, Concepción;
Macho, Antonio;
Calzado, Marco A.;
Blanco-Molina, Magdalena;
Minassi, Alberto;
Appendino, Giovanni;
Muñoz, Eduardo

Publication type:

Article