Complexes of Fe(III) and Ga(III) Derived from the Cyclic 6‐ and 7‐Membered Hydroxamic Acids Found in Mixed Siderophores.

Jewula, Pawel; Grandmougin, Mickaël; Choppin, Mélanie; Tivelli, Anna Maria Chiara; Amati, Agnese; Rousselin, Yoann; Karmazin, Lydia; Chambron, Jean‐Claude; Meyer, Michel

Six‐ and seven‐membered cyclic hydroxamic acids are found as terminal binding units in different families of siderophores, including exochelins and mycobactins. The simplest models of these preorganized chelating ligands were known, but their coordination chemistry with Fe3 , the target metal ion of siderophores, had never been reported. Four complexes were synthesized and studied: two Fe3 complexes, one with the six‐membered ring hydroxamate PIPO− and one with the seven‐membered ring hydroxamate AZEPO−, and the two corresponding Ga3 complexes. X‐ray diffraction studies showed that the interligand repulsion energies were better minimized in the case of the AZEPO− complexes whatever the metal cation considered, and that the Fe−O bond distances were shorter in [Fe(AZEPO)3] by comparison with [Fe(PIPO)3].

SIDEROPHORES; COORDINATE covalent bond; HYDROXAMIC acids; CHEMICAL bond lengths; METAL complexes; METAL ions; SCHIFF bases

European Journal of Inorganic Chemistry, 2023, Vol 26, Issue 13, p1

1434-1948

Academic Journal

10.1002/ejic.202300038