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MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7534, doi. 10.3390/ijms21207534
By:
- Keuls, Rachel A.;
- Kojima, Karin;
- Lozzi, Brittney;
- Steele, John W.;
- Chen, Qiuying;
- Gross, Steven S.;
- Finnell, Richard H.;
- Parchem, Ronald J.
Publication type:
Article
Effects of latrepirdine on Aβ clearance, neurotoxicity and aggregation
Published in:
2010
By:
- Martins, Ralph N.;
- Gandy, Sam E.;
- Gupta, Veer;
- Steele, John W.;
- Kim, Song H.;
- Cirrito, John;
- Lachenmayer, Lenard;
- Ehrlich, Michelle;
- Yue, Zhenyu;
- Bharadwaj, Prashant;
- Barr, Renae;
- Martins, Ian;
- Morici, Michael;
- Taddei, Kevin;
- Verdile, Giuseppe
Publication type:
Abstract
Latrepirdine enhances Aβ degradation in yeast via an autophagic pathway
Published in:
2010
By:
- Bharadwaj, Prashant R.;
- Barr, Renae;
- Lachenmayer, Lenard;
- Steele, John W.;
- Ehrlich, Michelle E.;
- Yue, Zhenyu;
- Gandy, Sam;
- Verdile, Giuseppe;
- Martins, Ralph
Publication type:
Abstract
Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain
Published in:
2010
By:
- Steele, John W.;
- Simon, Adam J.;
- Lublin, Alex L.;
- Lah, James J.;
- Walker, Lary C.;
- Levey, Allan I.;
- Krafft, Grant A.;
- Levy, Efrat;
- Glabe, Charles;
- Bilker, Warren;
- Abel, Ted;
- Schmeidler, James;
- Ehrlich, Michelle E.;
- Gandy, Sam
Publication type:
Abstract
Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back.
Published in:
Genesis: The Journal of Genetics & Development, 2021, v. 59, n. 11, p. 1, doi. 10.1002/dvg.23459
By:
- Wolujewicz, Paul;
- Steele, John W.;
- Kaltschmidt, Julia A.;
- Finnell, Richard H.;
- Ross, Margaret Elizabeth
Publication type:
Article
Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin.
Published in:
Scientific Reports, 2015, p. 17042, doi. 10.1038/srep17042
By:
- Brautigam, Hannah;
- Moreno, Cesar L.;
- Steele, John W.;
- Bogush, Alexey;
- Dickstein, Dara L.;
- Kwok, John B.J.;
- Schofield, Peter R.;
- Thinakaran, Gopal;
- Mathews, Paul M.;
- Hof, Patrick R.;
- Gandy, Sam;
- Ehrlich, Michelle E.
Publication type:
Article
Molecular Topology as Novel Strategy for Discovery of Drugs with Aβ Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092750
By:
- Wang, Jun;
- Land, David;
- Ono, Kenjiro;
- Galvez, Jorge;
- Zhao, Wei;
- Vempati, Prashant;
- Steele, John W.;
- Cheng, Alice;
- Yamada, Masahito;
- Levine, Samara;
- Mazzola, Paolo;
- Pasinetti, Giulio M.
Publication type:
Article
Characterization and Molecular Profiling of <i>PSEN1</i> Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084547
By:
- Sproul, Andrew A.;
- Jacob, Samson;
- Pre, Deborah;
- Kim, Soong Ho;
- Nestor, Michael W.;
- Navarro-Sobrino, Miriam;
- Santa-Maria, Ismael;
- Zimmer, Matthew;
- Aubry, Soline;
- Steele, John W.;
- Kahler, David J.;
- Dranovsky, Alex;
- Arancio, Ottavio;
- Crary, John F.;
- Gandy, Sam;
- Noggle, Scott A.
Publication type:
Article
Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster.
Published in:
PLoS Genetics, 2021, v. 17, n. 5, p. 1, doi. 10.1371/journal.pgen.1009544
By:
- Stevens, Leslie M.;
- Kim, Goheun;
- Koromila, Theodora;
- Steele, John W.;
- McGehee, James;
- Stathopoulos, Angelike;
- Stein, David S.
Publication type:
Article
Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model.
Published in:
Journal of Comparative Neurology, 2014, v. 522, n. 10, p. 2319, doi. 10.1002/cne.23536
By:
- Steele, John W.;
- Brautigam, Hannah;
- Short, Jennifer A.;
- Sowa, Allison;
- Shi, Mengxi;
- Yadav, Aniruddha;
- Weaver, Christina M.;
- Westaway, David;
- Fraser, Paul E.;
- St George‐Hyslop, Peter H.;
- Gandy, Sam;
- Hof, Patrick R.;
- Dickstein, Dara L.
Publication type:
Article
Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?
Published in:
2011
By:
- Steele JW;
- Gandy S;
- Steele, John W;
- Gandy, Sam
Publication type:
commentary
Apomorphine and Alzheimer Aβ: Roles for regulated α cleavage, autophagy, and antioxidation?
Published in:
Annals of Neurology, 2011, v. 69, n. 2, p. 221, doi. 10.1002/ana.22359
By:
- Steele, John W.;
- Gandy, Sam
Publication type:
Article
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.
Published in:
2010
By:
- Gandy S;
- Simon AJ;
- Steele JW;
- Lublin AL;
- Lah JJ;
- Walker LC;
- Levey AI;
- Krafft GA;
- Levy E;
- Checler F;
- Glabe C;
- Bilker WB;
- Abel T;
- Schmeidler J;
- Ehrlich ME;
- Gandy, Sam;
- Simon, Adam J;
- Steele, John W;
- Lublin, Alex L;
- Lah, James J
Publication type:
journal article
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers.
Published in:
Annals of Neurology, 2010, v. 68, n. 2, p. 220, doi. 10.1002/ana.22052
By:
- Gandy, Sam;
- Simon, Adam J.;
- Steele, John W.;
- Lublin, Alex L.;
- Lah, James J.;
- Walker, Lary C.;
- Levey, Allan I.;
- Krafft, Grant A.;
- Levy, Efrat;
- Checler, Frédéric;
- Glabe, Charles;
- Bilker, Warren B.;
- Abel, Ted;
- Schmeidler, James;
- Ehrlich, Michelle E.
Publication type:
Article
FKBP8 variants are risk factors for spina bifida.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 18, p. 3132, doi. 10.1093/hmg/ddaa211
By:
- Tian, Tian;
- Cao, Xuanye;
- Kim, Sung-Eun;
- Lin, Ying Linda;
- Steele, John W;
- Cabrera, Robert M;
- Karki, Menuka;
- Yang, Wei;
- Marini, Nicholas J;
- Hoffman, Ethan N;
- Han, Xiao;
- Hu, Cindy;
- Wang, Linlin;
- Wlodarczyk, Bogdan J;
- Shaw, Gary M;
- Ren, Aiguo;
- Finnell, Richard H;
- Lei, Yunping
Publication type:
Article
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 58, doi. 10.1186/1750-1326-7-58
By:
- Brautigam, Hannah;
- Steele, John W.;
- Westaway, David;
- Fraser, Paul E.;
- St George-Hyslop, Peter H.;
- Gandy, Sam;
- Hof, Patrick R.;
- Dickstein, Dara L.
Publication type:
Article
Loss of RAD9B impairs early neural development and contributes to the risk for human spina bifida.
Published in:
Human Mutation, 2020, v. 41, n. 4, p. 786, doi. 10.1002/humu.23969
By:
- Cao, Xuanye;
- Tian, Tian;
- Steele, John W.;
- Cabrera, Robert M.;
- Aguiar‐Pulido, Vanessa;
- Wadhwa, Shruti;
- Bhavani, Nikitha;
- Bi, Patrick;
- Gargurevich, Nick H.;
- Hoffman, Ethan N.;
- Cai, Chun‐Quan;
- Marini, Nicholas J.;
- Yang, Wei;
- Shaw, Gary M.;
- Ross, Margaret E.;
- Finnell, Richard H.;
- Lei, Yunping
Publication type:
Article
Excess folic acid intake increases DNA de novo point mutations.
Published in:
Cell Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41421-022-00512-0
By:
- Cao, Xuanye;
- Xu, Jianfeng;
- Lin, Ying L.;
- Cabrera, Robert M.;
- Chen, Qiuying;
- Zhang, Chaofan;
- Steele, John W.;
- Han, Xiao;
- Gross, Steven S.;
- Wlodarczyk, Bogdan J.;
- Lupski, James R.;
- Li, Wei;
- Wang, Hongyan;
- Finnell, Richard H.;
- Lei, Yunping
Publication type:
Article
Protein Sortin g Motifs in the Cytoplasmic Tail of SorCSl Control Generation of Alzheimer's Amyloid-ß Peptide.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 16, p. 7099, doi. 10.1523/JNEUROSCI.5270-12.2013
By:
- Lane, Rachel F.;
- Steele, John W.;
- Dongming Cai;
- Ehrlich, Michelle E.;
- Attie, Alan D.;
- Gandy, Sam
Publication type:
Article
Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 39, p. 13110, doi. 10.1523/JNEUROSCI.3872-10.2010
By:
- Lane, Rachel F.;
- Raines, Summer M.;
- Steele, John W.;
- Ehrlich, Michelle E.;
- Lah, James A.;
- Small, Scott A.;
- Tanzi, Rudolph E.;
- Attie, Alan D.;
- Gandy, Sam
Publication type:
Article

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