Results
Title

Type 2 diabetes, insulin treatment and prognosis of breast cancer.

Authors

Mu, Lan; Zhu, Nannan; Zhang, Jiao; Xing, Fang; Li, Daiqing; Wang, Xin

Abstract

Background: The aim of our study was to investigate whether pre-existing type 2 diabetes and insulin therapy have an impact on the prognosis of breast cancer patients.Methods: We performed a retrospective analysis of 462 type 2 diabetic breast cancer patients and 1644 non-diabetic breast cancer patients treated in our institute from January 2005 to August 2010. Patients were divided by diabetes status and insulin use. The clinicopathological characteristics and clinical outcomes of patients within 5 years following breast cancer diagnosed were analysed.Results: Diabetic patients tended to have higher body mass index and higher histological grade tumours. Five-year disease-free survival and overall survival were reduced in diabetic patients (P Conclusions: Type 2 diabetes and insulin treatment might be independently associated with poorer prognosis of breast cancer. However, caution is needed when interpreting our results, and further investigations are needed. Copyright © 2016 John Wiley & Sons, Ltd.

Subjects

INSULIN therapy; HYPOGLYCEMIC agents; TYPE 2 diabetes complications; BREAST tumors; TYPE 2 diabetes; PROGNOSIS; DISEASE complications

Publication

Diabetes/Metabolism Research & Reviews, 2017, Vol 33, Issue 1, pn/a

ISSN

1520-7552

Publication type

Academic Journal

DOI

10.1002/dmrr.2823