Results
Title

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults.

Authors

Lu, Jun; Hou, Xuhong; Pang, Can; Zhang, Lei; Hu, Cheng; Zhao, Jungong; Bao, Yuqian; Jia, Weiping

Abstract

Aims: This study aimed to compare pancreatic volume and its clinical significance among patients with type 2 diabetes mellitus (DM), adult-onset type 1 DM and latent autoimmune diabetes in adults (LADA).Methods: This is a cross-sectional study. One hundred twenty-six outpatients (68 with LADA and 58 with type 1 DM) and 158 inpatients (71 with type 2 DM and 87 non-diabetic controls) were recruited during May-July 2013 in Shanghai Jiao Tong University Affiliated Sixth People's Hospital. All the patients underwent abdominal computerized tomography; pancreatic volume was then calculated.Results: The mean pancreatic volume was highest in the controls, followed by those in patients with type 2 DM, LADA and type 1 DM. The pancreatic volume in LADA was comparable with that in type 2 DM but significantly greater than that in type 1 DM (p Conclusions: Pancreatic atrophy in LADA was less marked than in type 1 DM. Pancreatic atrophy may suggest reduced level of fasting C-peptide in patients with LADA. Copyright © 2016 John Wiley & Sons, Ltd.

Subjects

CHINA; TYPE 2 diabetes complications; COMPARATIVE studies; TYPE 1 diabetes; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; PANCREAS; PROGNOSIS; RESEARCH; EVALUATION research; CROSS-sectional method; CASE-control method; DISEASE complications

Publication

Diabetes/Metabolism Research & Reviews, 2016, Vol 32, Issue 8, p858

ISSN

1520-7552

Publication type

Academic Journal

DOI

10.1002/dmrr.2806