Short-term intensive insulin therapy at diagnosis in type 2 diabetes: plan for filling the gaps.

Weng, Jianping; Retnakaran, Ravi; Ariachery C, Ammini; Ji, Linong; Meneghini, Luigi; Yang, Wenying; Woo, Jeong‐Taek

Short-term intensive insulin therapy is unique amongst therapies for type 2 diabetes because it offers the potential to preserve and improve beta-cell function without additional pharmacological treatment. On the basis of clinical experience and the promising results of a series of studies in newly diagnosed patients, mostly in Asian populations, an expert workshop was convened to assess the available evidence and the potential application of short-term intensive insulin therapy should it be advocated for inclusion in clinical practice. Participants included primary care physicians and endocrinologists. We endorse the concept of short-term intensive insulin therapy as an option for some patients with type 2 diabetes at the time of diagnosis and have identified the following six areas where additional knowledge could help clarify optimal use in clinical practice: (1) generalizability to primary care, (2) target population and biomarkers, (3) follow-up treatment, (4) education of patients and providers, (5) relevance of ethnicity, and (6) health economics.

INSULIN therapy; TYPE 2 diabetes diagnosis; HYPOGLYCEMIC agents; ANIMALS; CONFERENCES & conventions; INSULIN; INSULIN resistance; ISLANDS of Langerhans; MEDICAL protocols; TYPE 2 diabetes; EVIDENCE-based medicine; DISEASE remission; EARLY diagnosis

Diabetes/Metabolism Research & Reviews, 2015, Vol 31, Issue 6, p537

1520-7552

Academic Journal

10.1002/dmrr.2603