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- Title
Antileishmanial Activity of Natural Product-Like Naphthoquinones.
- Authors
Malerich, Jeremiah P.; Li, Jinfang; Joder, Dallas; Vieria, Érica L. M.; Keesen, Tatjana S. L.; Vaidyanathan, Rajeev; Gollob, Kenneth J.; Tanga, Mary J.
- Abstract
The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolitesfrom Bignoniaceae is presented. Three structural series of compounds from a common biosyntheticpathway were evaluated against Leishmania major. Compound (15), an analog of the natural productpinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensisand L. infantum, compound 15 showed similar activity to amphotericin B. Drug Dev Res 74 :237-241, 2013.
- Subjects
NAPHTHOQUINONE; LEISHMANIASIS treatment; BIGNONIACEAE; BIOSYNTHESIS; AMPHOTERICIN B; LEISHMANIA; LEISHMANIA infantum
- Publication
Drug Development Research, 2013, Vol 74, Issue 4, p237
- ISSN
0272-4391
- Publication type
Academic Journal
- DOI
10.1002/ddr.21067