Title: Antileishmanial Activity of Natural Product-Like Naphthoquinones.
Authors: Malerich, Jeremiah P.; Li, Jinfang; Joder, Dallas; Vieria, Érica L. M.; Keesen, Tatjana S. L.; Vaidyanathan, Rajeev; Gollob, Kenneth J.; Tanga, Mary J.
Abstract: The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolitesfrom Bignoniaceae is presented. Three structural series of compounds from a common biosyntheticpathway were evaluated against Leishmania major. Compound (15), an analog of the natural productpinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensisand L. infantum, compound 15 showed similar activity to amphotericin B. Drug Dev Res 74 :237-241, 2013.
Subjects: NAPHTHOQUINONE; LEISHMANIASIS treatment; BIGNONIACEAE; BIOSYNTHESIS; AMPHOTERICIN B; LEISHMANIA; LEISHMANIA infantum
Publication: Drug Development Research, 2013, Vol 74, Issue 4, p237
ISSN: 0272-4391
Publication type: Academic Journal
DOI: 10.1002/ddr.21067

Antileishmanial Activity of Natural Product-Like Naphthoquinones.

Malerich, Jeremiah P.; Li, Jinfang; Joder, Dallas; Vieria, Érica L. M.; Keesen, Tatjana S. L.; Vaidyanathan, Rajeev; Gollob, Kenneth J.; Tanga, Mary J.