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Title: A Randomized Phase 2 Trial Comparing 3-Hour Versus 96-Hour Infusion Schedules of Paclitaxel for the Treatment of Metastatic Breast Cancer.
Authors: Moulder, Stacy L.; Holmes, Frankie A.; Tolcher, Anthony W.; Thall, Peter; Broglio, Kristine; Valero, Vicente; Buzdar, Aman U.; Arbuck, Susan G.; Seidman, Andrew; Hortobagyi, Gabriel N.
Abstract: The article presents a study which compares the toxicity and efficacy profile of 96-hour and three-hour infusion schedule of paclitaxel in treating metastatic breast cancer (MBC). The study evaluated the response of patients with MBC on chemotherapy regimens using bidimensional measurements. Results show that patients' response rate on both schedules was similar. It concludes that paclitaxel was active in MBC either in 96-hour and three-hour infusion schedules.
Subjects: BREAST cancer treatment; PACLITAXEL; DRUG efficacy; CANCER patients; TOXICITY testing; DRUG therapy
Publication: Cancer (0008543X), 2010, Vol 116, Issue 4, p814
ISSN: 0008-543X
Publication type: Academic Journal
DOI: 10.1002/cncr.24870

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A Randomized Phase 2 Trial Comparing 3-Hour Versus 96-Hour Infusion Schedules of Paclitaxel for the Treatment of Metastatic Breast Cancer.