Works matching DE "CYCLIN-dependent kinases"

Results: 3957

Continuing Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Advanced Breast Cancer: A Meta-Analysis †.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1609, doi. 10.3390/cancers17101609

By:

Pathak, Neha;
Kumar, Sudhir;
Gimenez, Diego Malon;
Di Iorio, Massimo;
Savill, Jacqueline;
Berner-Wygoda, Yael;
Li, Meredith;
Valiente, Consolacion Molto;
Cuthbert, Danielle;
Gupta, Aarushi;
Arteaga, Diana P.;
Batra, Atul;
Amir, Eitan;
Mittal, Abhenil

Publication type:

Article

Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation.

Published in:

Neurogenetics, 2006, v. 7, n. 1, p. 59, doi. 10.1007/s10048-005-0026-9

By:

Venturin, Marco;
Moncini, Silvia;
Villa, Valentina;
Russo, Silvia;
Bonati, Maria;
Larizza, Lidia;
Riva, Paola

Publication type:

Article

CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 396, doi. 10.1038/nsmb.3000

By:

Laitem, Clélia;
Zaborowska, Justyna;
Isa, Nur F;
Kufs, Johann;
Dienstbier, Martin;
Murphy, Shona

Publication type:

Article

A bumpy road for RNA polymerase II.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 353, doi. 10.1038/nsmb.3020

By:

Giono, Luciana E;
Kornblihtt, Alberto R

Publication type:

Article

Multisite phosphorylation networks as signal processors for Cdk1.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1415, doi. 10.1038/nsmb.2706

By:

Kõivomägi, Mardo;
Örd, Mihkel;
Iofik, Anna;
Valk, Ervin;
Venta, Rainis;
Faustova, Ilona;
Kivi, Rait;
Balog, Eva Rose M;
Rubin, Seth M;
Loog, Mart

Publication type:

Article

Cks confers specificity to phosphorylation-dependent CDK signaling pathways.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1407, doi. 10.1038/nsmb.2707

By:

McGrath, Denise A;
Balog, Eva Rose M;
Kõivomägi, Mardo;
Lucena, Rafael;
Mai, Michelle V;
Hirschi, Alexander;
Kellogg, Douglas R;
Loog, Mart;
Rubin, Seth M

Publication type:

Article

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1108, doi. 10.1038/nsmb.2399

By:

Larochelle, Stéphane;
Amat, Ramon;
Glover-Cutter, Kira;
Sansó, Miriam;
Zhang, Chao;
Allen, Jasmina J;
Shokat, Kevan M;
Bentley, David L;
Fisher, Robert P

Publication type:

Article

Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1101, doi. 10.1038/nsmb.2404

By:

Hughes, Siobhan;
Elustondo, Frédéric;
Di Fonzo, Andrea;
Leroux, Frédéric G;
Wong, Ai C;
Snijders, Ambrosius P;
Matthews, Stephen J;
Cherepanov, Peter

Publication type:

Article

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 246, doi. 10.1038/nsmb.2212

By:

Buis, Jeffrey;
Stoneham, Trina;
Spehalski, Elizabeth;
Ferguson, David O

Publication type:

Article

Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1065, doi. 10.1038/nsmb.1878

By:

Maeshima, Kazuhiro;
Iino, Haruki;
Hihara, Saera;
Funakoshi, Tomoko;
Watanabe, Ai;
Nishimura, Masaomi;
Nakatomi, Reiko;
Yahata, Kazuhide;
Imamoto, Fumio;
Hashikawa, Tsutomu;
Yokota, Hideo;
Imamoto, Naoko

Publication type:

Article

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 194, doi. 10.1038/nsmb.1752

By:

Donner, Aaron J.;
Ebmeier, Christopher C.;
Taatjes, Dylan J.;
Espinosa, Joaquín M.

Publication type:

Article

Structural insights into the Cyclin T1–Tat–TAR RNA transcription activation complex from EIAV.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1287, doi. 10.1038/nsmb.1513

By:

Anand, Kanchan;
Schulte, Antje;
Vogel-Bachmayr, Karin;
Scheffzek, Klaus;
Geyer, Matthias

Publication type:

Article

CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 10, p. 908, doi. 10.1038/nsmb1139

By:

Wysocki, Robert;
Javaheri, Ali;
Kristjansdottir, Kolbrun;
Sha, Fei;
Kron, Stephen J.

Publication type:

Article

MONALEESA-2 Trial—A Beacon of Hope.

Published in:

2025

By:

Tripathi, Mayank;
Vineet, Kumar

Publication type:

Letter

Chemically induced premature chromosome condensation in short-term cultured human peripheral lymphocytes: applications to biodosimetry.

Published in:

Biotechnic & Histochemistry, 2007, v. 82, n. 1, p. 29, doi. 10.1080/10520290701257153

By:

Tsuji, S;
Kanda, R

Publication type:

Article

Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.

Published in:

Veterinary & Comparative Oncology, 2017, v. 15, n. 4, p. 1479, doi. 10.1111/vco.12293

By:

Ozmen, O.;
Kul, S.;
Risvanli, A.;
Ozalp, G.;
Sabuncu, A.;
Kul, O.

Publication type:

Article

Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy.

Published in:

Angewandte Chemie, 2014, v. 126, n. 20, p. 5202, doi. 10.1002/ange.201310618

By:

Koh, Minseob;
Park, Jongmin;
Koo, Ja Young;
Lim, Donghyun;
Cha, Mi Young;
Jo, Ala;
Choi, Jang Hyun;
Park, Seung Bum

Publication type:

Article

Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.

Published in:

Chromosome Research, 2024, v. 32, n. 4, p. 1, doi. 10.1007/s10577-024-09756-w

By:

Halter, Kevin;
Chen, Jingyi;
Priklopil, Tadeas;
Monfort, Asun;
Wutz, Anton

Publication type:

Article

How to be a mitotic chromosome.

Published in:

Chromosome Research, 2011, v. 19, n. 3, p. 307, doi. 10.1007/s10577-011-9198-3

By:

Moser, Sandra;
Swedlow, Jason

Publication type:

Article

Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 2, p. 654, doi. 10.1002/med.21856

By:

Bhurta, Deendyal;
Bharate, Sandip B.

Publication type:

Article

How selective are clinical CDK4/6 inhibitors?

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 3, p. 1578, doi. 10.1002/med.21769

By:

Hendrychová, Denisa;
Jorda, Radek;
Kryštof, Vladimír

Publication type:

Article

Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4–retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi.

Published in:

Urological Research, 2006, v. 34, n. 5, p. 321, doi. 10.1007/s00240-006-0063-3

By:

Lunbiao Cui;
Yuan Shi;
Jie Qian;
Guidong Dai;
Yubang Wang;
Yankai Xia;
Jianfeng Chen;
Ling Song;
Shouling Wang;
Xinru Wang

Publication type:

Article

Epigenetic modulation of Cdk5 contributes to memory deficiency induced by amyloid fibrils.

Published in:

Experimental Brain Research, 2015, v. 233, n. 1, p. 165, doi. 10.1007/s00221-014-4100-0

By:

Li, Liuhong;
Zhang, Chunqiang;
Zi, Xiaohong;
Tu, Qiuyun;
Guo, Ke

Publication type:

Article

AMPA receptor phosphorylation and recognition memory: learning-related, time-dependent changes in the chick brain following filial imprinting.

Published in:

Experimental Brain Research, 2013, v. 226, n. 2, p. 297, doi. 10.1007/s00221-013-3435-2

By:

Solomonia, Revaz;
Meparishvili, Maia;
Mikautadze, Ekaterine;
Kunelauri, Nana;
Apkhazava, David;
McCabe, Brian

Publication type:

Article

Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 12, p. 1893, doi. 10.1007/s00228-024-03757-8

By:

Yang, Ping;
Zhang, Hengheng;
Wu, Meijie;
Zhao, Fuxing;
Wang, Miaozhou;
Zhao, Jiuda;
Zhao, Yi

Publication type:

Article

Quantitative evaluation of the efficacy and safety profiles of two types of targeted inhibitors combined with endocrine therapy in ER+/HER2− metastatic breast cancer.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 9, p. 1387, doi. 10.1007/s00228-024-03715-4

By:

Pan, Meiyu;
Lin, Yan;
Liu, Yinhui;
Xu, Ruijuan;
Yang, Jin

Publication type:

Article

The effect of concomitant use of proton pump inhibitors with CDK 4/6 inhibitors on survival in metastatic breast cancer.

Published in:

European Journal of Clinical Pharmacology, 2023, v. 79, n. 2, p. 243, doi. 10.1007/s00228-022-03435-7

By:

Çağlayan, Dilek;
Koçak, Mehmet Zahid;
Geredeli, Çağlayan;
Tatlı, Ali Murat;
Göksu, Sema Sezgin;
Eryılmaz, Melek Karakurt;
Araz, Murat;
Artaç, Mehmet

Publication type:

Article

Metabolic changes during cell growth inhibition by p27 overexpression.

Published in:

Applied Microbiology & Biotechnology, 2003, v. 63, n. 2, p. 164, doi. 10.1007/s00253-003-1385-5

By:

Carvalhal, A. V.;
Marcelino, I.;
Carrondo, M. J. T.

Publication type:

Article

Investigation of the impact of PTMs on the protein backbone conformation.

Published in:

Amino Acids, 2019, v. 51, n. 7, p. 1065, doi. 10.1007/s00726-019-02747-w

By:

Craveur, Pierrick;
Narwani, Tarun J.;
Rebehmed, Joseph;
de Brevern, Alexandre G.

Publication type:

Article

CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.

Published in:

Amino Acids, 2016, v. 48, n. 2, p. 579, doi. 10.1007/s00726-015-2114-y

By:

Ianes, Chiara;
Xu, Pengfei;
Werz, Natalie;
Meng, Zhigang;
Henne-Bruns, Doris;
Bischof, Joachim;
Knippschild, Uwe

Publication type:

Article

O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2.

Published in:

Amino Acids, 2013, v. 45, n. 2, p. 339, doi. 10.1007/s00726-013-1504-2

By:

Ding, Fang;
Yu, Lu;
Wang, Meihui;
Xu, Shengjie;
Xia, Qiang;
Fu, Guosheng

Publication type:

Article

Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.

Published in:

Amino Acids, 2012, v. 42, n. 2/3, p. 655, doi. 10.1007/s00726-011-1040-x

By:

Arısan, Elif;
Çoker, Ajda;
Palavan-Ünsal, Narçin

Publication type:

Article

Skp2 inversely correlates with p27 and tuberin in transformed cells.

Published in:

Amino Acids, 2009, v. 37, n. 2, p. 257, doi. 10.1007/s00726-008-0141-7

By:

M. Rosner;
M. Hanneder;
N. Siegel;
A. Valli;
C. Fuchs;
M. HengstschlÃ¤ger

Publication type:

Article

Role of Protein Kinase C in Substance P-Induced Synaptic Depression in the Nucleus Accumbens in vitro.

Published in:

Medical Principles & Practice, 2007, v. 16, n. 2, p. 90, doi. 10.1159/000098359

By:

Matowe, W. C.;
Ananthalakshmi, K. V. V.;
Kombian, S. B.

Publication type:

Article

MicroRNA-93 Targets p21 and Promotes Proliferation in Mycosis Fungoides T Cells.

Published in:

Dermatology (10188665), 2021, v. 237, n. 2, p. 277, doi. 10.1159/000505743

By:

Gluud, Maria;
Fredholm, Simon;
Blümel, Edda;
Willerslev-Olsen, Andreas;
Buus, Terkild Brink;
Nastasi, Claudia;
Krejsgaard, Thorbjørn;
Bonefeld, Charlotte Menné;
Woetmann, Anders;
Iversen, Lars;
Litman, Thomas;
Geisler, Carsten;
Ødum, Niels;
Lindahl, Lise M.

Publication type:

Article

Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.

Published in:

Biochemical Journal, 2022, v. 479, n. 22, p. 2379, doi. 10.1042/BCJ20220391

By:

Misun Jung;
Wonyoung Kim;
Jin Won Cho;
Won Ho Yang;
In Kwon Chung

Publication type:

Article

The Prevalence and Prognostic Relevance of ABO/Rh Blood Groups in Metastatic Breast Cancer Patients Undergoing Cyclin-Dependent Kinase 4/6 Inhibitors Therapy.

Published in:

Eurasian Journal of Medical Investigation, 2024, v. 8, n. 3, p. 212, doi. 10.14744/ejmi.2024.49619

By:

Akdag, Goncagul;
Dogan, Akif;
Yildirim, Sedat;
Kinikoglu, Oguzcan;
Kudu, Emre;
Surmeli, Heves;
Isik, Deniz;
Sever, Ozlem Nuray;
Odabas, Hatice;
Yildirim, Mahmut Emre;
Turan, Nedim

Publication type:

Article

Investigation of the apoptotic and cell cycle effects of sorafenib and doxorubicin on URG4/URGCP in leukemia cells.

Published in:

Pamukkale Medical Journal, 2024, v. 17, n. 3, p. 498, doi. 10.31362/patd.1476105

By:

Dodurga, Yavuz;
Elmas, Levent;
Seçme, Mücahit;
Demirkıran, Nazlı;
Avcı, Çığır Biray;
Bağcı, Gülseren;
Sağ, Sevda;
Tufan, Lale Şatıroğlu

Publication type:

Article

A Sensitive, Green, and Fast LC–MS/MS Analytical Method for the Quantification of Ribociclib: Evaluation of the Metabolic Stability in HLMs.

Published in:

Separations (2297-8739), 2023, v. 10, n. 9, p. 472, doi. 10.3390/separations10090472

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-024-00787-4

By:

Kim, Daehwan;
Chung, Heekyung;
Liu, Wen;
Jeong, Kangjin;
Ozmen, Tugba Y.;
Ozmen, Furkan;
Rames, Matthew J.;
Kim, Sangyub;
Guo, Xiao;
Jameson, Nathan;
de Jong, Petrus R.;
Yea, Steven;
Harford, Laurie;
Li, Jiali;
Mathews, Cara A.;
Doroshow, Deborah B.;
Charles, Vincent J.;
Kim, Doris;
Fischer, Kimberlee;
Samatar, Ahmed A.

Publication type:

Article

Large-scale analysis of CDH1 mutations defines a distinctive molecular subset with treatment implications in gastric cancer.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00694-8

By:

Wang, Jingyuan;
Xiu, Joanne;
Battaglin, Francesca;
Arai, Hiroyuki;
Soni, Shivani;
Zhang, Wu;
Goldberg, Richard M.;
Philip, Philip A.;
Seeber, Andreas;
Hwang, Jimmy J.;
Shields, Anthony F.;
Marshall, John L.;
Astaturov, Igor;
Liu, Tianshu;
Lockhart, A. Craig;
Korn, W. Michael;
Shen, Lin;
Lenz, Heinz-Josef

Publication type:

Article

Osimertinib and palbociclib in an EGFR-mutated NSCLC with primary CDK4 amplification after progression under osimertinib.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00607-9

By:

de Jager, Vincent D.;
Stigt, Jos A.;
Niemantsverdriet, Maarten;
ter Elst, Arja;
van der Wekken, Anthonie J.

Publication type:

Article

Targeting CDK1 in cancer: mechanisms and implications.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00407-7

By:

Wang, Qiushi;
Bode, Ann M.;
Zhang, Tianshun

Publication type:

Article

CHALLENGES IN VARIANT CURATION IN PROSTATE CANCER.

Published in:

Genetics & Applications, 2023, p. 76

By:

Jesenka, Kazazović;
Amina, Kurtović-Kozarić

Publication type:

Article

Racial Differences in ctDNA Profiles, Targeted Therapy Use, and Outcomes in Metastatic Breast Cancer.

Published in:

JAMA Network Open, 2025, v. 8, n. 2, p. e2461899, doi. 10.1001/jamanetworkopen.2024.61899

By:

Podany, Emily L.;
Foffano, Lorenzo;
Gerratana, Lorenzo;
Medford, Arielle J.;
Clifton, Katherine;
Tapiavala, Shaili;
Velimirovic, Marko;
Lipsyc-Sharf, Marla;
Reduzzi, Carolina;
Bubie, Adrian;
Putur, Annika;
Ademuyiwa, Foluso O.;
Puglisi, Fabio;
Gradishar, William J.;
Ma, Cynthia X.;
Bardia, Aditya;
Cristofanilli, Massimo;
Davis, Andrew A.

Publication type:

Article

Survival Following CDK4/6 Inhibitor Therapy for Hormone Receptor–Positive, ERBB2–Negative Metastatic Breast Cancer.

Published in:

JAMA Network Open, 2025, v. 8, n. 2, p. e2461067, doi. 10.1001/jamanetworkopen.2024.61067

By:

Berton Giachetti, Pier Paolo Maria;
Morganti, Stefania;
Gandini, Sara;
Giudici, Fabiola;
Marra, Antonio;
Nicolò, Eleonora;
Zattarin, Emma;
Corti, Chiara;
Boldrini, Laura;
Verrazzo, Annarita;
Sposetti, Caterina;
Razeti, Maria Grazia;
Carnevale Schianca, Ambra;
Scafetta, Roberta;
Taurelli Salimbeni, Beatrice;
Esposito, Angela;
Zagami, Paola;
Trapani, Dario;
Malagutti, Bianca;
Caputo, Roberta

Publication type:

Article

Toward Optimization of Post-CDK4/6 Inhibitor Therapy.

Published in:

2025

By:

Foldi, Julia;
Brufsky, Adam

Publication type:

Opinion

QTc prolongation across CDK4/6 inhibitors: a systematic review and meta-analysis of randomized controlled trials.

Published in:

JNCI Cancer Spectrum, 2024, v. 8, n. 5, p. 1, doi. 10.1093/jncics/pkae078

By:

Murad, Bruno;
Reis, Pedro C A;
Marinho, Alice Deberaldini;
Comini, Ana Carolina Marin;
Xavier, Débora Pinheiro;
Pessoa, Beatriz Mella Soares;
Raheem, Farah;
Ernst, Brenda;
Mina, Lida A;
Batalini, Felipe

Publication type:

Article

Double-Faced Immunological Effects of CDK4/6 Inhibitors on Cancer Treatment: Challenges and Perspectives.

Published in:

Bioengineering (Basel), 2024, v. 11, n. 11, p. 1084, doi. 10.3390/bioengineering11111084

By:

Liu, Yongqin;
Deng, Yiying;
Yang, Chang;
Naranmandura, Hua

Publication type:

Article

Implication of TRPM8, CD47, and CDK4 expressions in hepatocellular carcinoma progression.

Published in:

Journal of Immunoassay & Immunochemistry, 2025, v. 46, n. 3, p. 245, doi. 10.1080/15321819.2025.2464718

By:

Hemida, Aiat Shaban;
Tantawy, Mona Saeed

Publication type:

Article