Works matching DE "PRODRUGS"

Results: 1657

Radiation‐Responsive Benzothiazolines as Potential Cleavable Fluorogenic Linkers for Drug Delivery.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 31, p. 1, doi. 10.1002/chem.202300358

By:

Tuo, Wei;
Renault, Jean‐Philippe;
Rajpal, Aashini;
Pin, Serge;
Le Gall, Thierry;
Taran, Frédéric

Publication type:

Article

Pillararene‐Based Supramolecular Vesicles for Stimuli‐Responsive Drug Delivery.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 71, p. 1, doi. 10.1002/chem.202202050

By:

Wang, Chen;
Li, Hang;
Dong, Jiangtao;
Chen, Yuxia;
Luan, Xingkun;
Li, Xiaona;
Du, Xuezhong

Publication type:

Article

Peroxynitrite‐Promoted Persulfide Prodrugs with Protective Potential against Paracetamol Poisoning.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 36, p. 1, doi. 10.1002/chem.202200540

By:

Xu, Ya‐Wen;
Xu, Bi‐Xin;
Wang, Jiankun;
Jin, Hao‐Wen;
Xu, Si‐Tao;
Wang, Guangji;
Zhen, Le

Publication type:

Article

Chloromethyl Glycosides as Versatile Synthons to Prepare Glycosyloxymethyl‐Prodrugs.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 9, p. 1, doi. 10.1002/chem.202103910

By:

Elferink, Hidde;
Titulaer, Willem H. C.;
Derks, Maik G. N.;
Veeneman, Gerrit H.;
Rutjes, Floris P. J. T.;
Boltje, Thomas J.

Publication type:

Article

Real‐Time Multi‐Photon Tracking and Bioimaging of Glycosylated Theranostic Prodrugs upon Specific Enzyme Triggered Release.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 3, p. 1, doi. 10.1002/chem.202103858

By:

Calatrava‐Pérez, Elena;
Marchetti, Luke A.;
McManus, Gavin J.;
Lynch, Dylan M.;
Elmes, Robert B. P.;
Williams, D. Clive;
Gunnlaugsson, Thorfinnur;
Scanlan, Eoin M.

Publication type:

Article

Computational Analysis of Photophysical Properties and Reactivity of a New Phototherapeutic Cyclometalated Au(III)‐Hydride Complex.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 62, p. 15528, doi. 10.1002/chem.202102701

By:

Scoditti, Stefano;
Mazzone, Gloria;
Sicilia, Emilia

Publication type:

Article

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 11, p. 3806, doi. 10.1002/chem.202004694

By:

Haren, Matthijs J.;
Tehrani, Kamaleddin H. M. E.;
Kotsogianni, Ioli;
Wade, Nicola;
Brüchle, Nora C.;
Mashayekhi, Vida;
Martin, Nathaniel I.

Publication type:

Article

Frontispiece: Light‐Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 48, p. 1, doi. 10.1002/chem.202084864

By:

Geri, Stepan;
Krunclova, Tereza;
Janouskova, Olga;
Panek, Jiri;
Hruby, Martin;
Hernández‐Valdés, Daniel;
Probst, Benjamin;
Alberto, Roger A.;
Mamat, Constantin;
Kubeil, Manja;
Stephan, Holger

Publication type:

Article

Light‐Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 48, p. 10992, doi. 10.1002/chem.202002139

By:

Geri, Stepan;
Krunclova, Tereza;
Janouskova, Olga;
Panek, Jiri;
Hruby, Martin;
Hernández‐Valdés, Daniel;
Probst, Benjamin;
Alberto, Roger A.;
Mamat, Constantin;
Kubeil, Manja;
Stephan, Holger

Publication type:

Article

Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy.

Published in:

Chemistry - A European Journal, 2019, v. 25, n. 68, p. 15662, doi. 10.1002/chem.201903976

By:

Gaillard, Boris;
Seguin, Cendrine;
Remy, Jean‐Serge;
Pons, Françoise;
Lebeau, Luc

Publication type:

Article

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

Published in:

Angewandte Chemie, 2016, v. 128, n. 17, p. 5341, doi. 10.1002/ange.201511808

By:

Gollnest, Tristan;
Dinis de Oliveira, Thiago;
Rath, Anna;
Hauber, Ilona;
Schols, Dominique;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide.

Published in:

Angewandte Chemie, 2016, v. 128, n. 14, p. 4590, doi. 10.1002/ange.201511244

By:

Zheng, Yueqin;
Yu, Bingchen;
Ji, Kaili;
Pan, Zhixiang;
Chittavong, Vayou;
Wang, Binghe

Publication type:

Article

Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells.

Published in:

Angewandte Chemie, 2015, v. 127, n. 45, p. 13505, doi. 10.1002/ange.201507157

By:

Li, Jie;
Kuang, Yi;
Shi, Junfeng;
Zhou, Jie;
Medina, Jamie E.;
Zhou, Rong;
Yuan, Dan;
Yang, Cuihong;
Wang, Huaimin;
Yang, Zhimou;
Liu, Jianfeng;
Dinulescu, Daniela M.;
Xu, Bing

Publication type:

Article

Ring-Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well-Defined Drug-Loaded Nanoparticles.

Published in:

Angewandte Chemie, 2015, v. 127, n. 3, p. 1016, doi. 10.1002/ange.201409293

By:

Liu, Jinyao;
Liu, Wenge;
Weitzhandler, Isaac;
Bhattacharyya, Jayanta;
Li, Xinghai;
Wang, Jing;
Qi, Yizhi;
Bhattacharjee, Somnath;
Chilkoti, Ashutosh

Publication type:

Article

Cyclic-Disulfide-Based Prodrugs for Cytosol-Specific Drug Delivery.

Published in:

Angewandte Chemie, 2014, v. 126, n. 51, p. 14270, doi. 10.1002/ange.201407130

By:

Butora, Gabor;
Qi, Ning;
Fu, Wenlang;
Nguyen, Truyen;
Huang, Hsueh ‐ Cheng;
Davies, Ian W.

Publication type:

Article

Structure-Based Rational Design of Prodrugs To Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy.

Published in:

Angewandte Chemie, 2014, v. 126, n. 43, p. 11716, doi. 10.1002/ange.201406685

By:

Wang, Hangxiang;
Xie, Haiyang;
Wu, Jiaping;
Wei, Xuyong;
Zhou, Lin;
Xu, Xiao;
Zheng, Shusen

Publication type:

Article

Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells.

Published in:

Angewandte Chemie, 2014, v. 126, n. 32, p. 8532, doi. 10.1002/ange.201404238

By:

Brülisauer, Lorine;
Valentino, Gina;
Morinaga, Sakura;
Cam, Kübra;
Thostrup Bukrinski, Jens;
Gauthier, Marc A.;
Leroux, Jean ‐ Christophe

Publication type:

Article

Conjugated-Polyelectrolyte-Based Polyprodrug: Targeted and Image-Guided Photodynamic and Chemotherapy with On-Demand Drug Release upon Irradiation with a Single Light Source.

Published in:

Angewandte Chemie, 2014, v. 126, n. 28, p. 7291, doi. 10.1002/ange.201402189

By:

Yuan, Youyong;
Liu, Jie;
Liu, Bin

Publication type:

Article

Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents.

Published in:

Angewandte Chemie, 2014, v. 126, n. 26, p. 6870, doi. 10.1002/ange.201402879

By:

Wong, Daniel Yuan Qiang;
Yeo, Charmian Hui Fang;
Ang, Wee Han

Publication type:

Article

The Prodrug Platin- A: Simultaneous Release of Cisplatin and Aspirin.

Published in:

Angewandte Chemie, 2014, v. 126, n. 7, p. 1994, doi. 10.1002/ange.201308899

By:

Pathak, Rakesh K.;
Marrache, Sean;
Choi, Joshua H.;
Berding, Trenton B.;
Dhar, Shanta

Publication type:

Article

Near-Infrared Light-Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging by Upconversion-Luminescent Nanoparticles.

Published in:

Angewandte Chemie, 2014, v. 126, n. 4, p. 1030, doi. 10.1002/ange.201308834

By:

Min, Yuanzeng;
Li, Jinming;
Liu, Fang;
Yeow, Edwin K. L.;
Xing, Bengang

Publication type:

Article

Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor.

Published in:

Angewandte Chemie, 2014, v. 126, n. 1, p. 203, doi. 10.1002/ange.201307387

By:

Lim, Sang Min;
Westover, Kenneth D.;
Ficarro, Scott B.;
Harrison, Rane A.;
Choi, Hwan Geun;
Pacold, Michael E.;
Carrasco, Martin;
Hunter, John;
Kim, Nam Doo;
Xie, Ting;
Sim, Taebo;
Jänne, Pasi A.;
Meyerson, Matthew;
Marto, Jarrod A.;
Engen, John R.;
Gray, Nathanael S.

Publication type:

Article

A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold.

Published in:

Angewandte Chemie, 2013, v. 125, n. 45, p. 12001, doi. 10.1002/ange.201305734

By:

Montagner, Diego;
Yap, Siew Qi;
Ang, Wee Han

Publication type:

Article

Advances in the Delivery, Activation and Therapeutics Applications of Bioorthogonal Prodrugs.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 3, p. 887, doi. 10.1002/med.22095

By:

Zhou, Zhou;
Sun, Yuanjun;
Pang, Jing;
Long, Ya‐Qiu

Publication type:

Article

Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 4, p. 1545, doi. 10.1002/med.22021

By:

Ma, Xiaoyan;
Wang, Zhaoran;
Li, Yifei;
Wang, Yawen;
Liu, Wukun

Publication type:

Article

Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 3, p. 1013, doi. 10.1002/med.22007

By:

Zhao, Jintao;
Li, Xinming;
Ma, Tao;
Chang, Bingbing;
Zhang, Baoxin;
Fang, Jianguo

Publication type:

Article

In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss.

Published in:

Osteoporosis International, 2016, v. 27, n. 2, p. 797, doi. 10.1007/s00198-015-3284-x

By:

Hu, S.;
Liu, C.;
Willett, T.;
Grynpas, M.;
Chen, G.;
Young, R.

Publication type:

Article

Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system.

Published in:

2017

By:

Sun, He;
Li, Haona;
Ren, Xuequn;
Deng, Jianxiong;
Zhang, Yiexiang;
Yue, Zhihua

Publication type:

Letter

Effects of ranitidine (antacid), food, and formulation on the pharmacokinetics of fostamatinib: results from five phase I clinical studies.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 2, p. 185, doi. 10.1007/s00228-016-2156-4

By:

Flanagan, Talia;
Martin, Paul;
Gillen, Michael;
Mathews, David;
Lisbon, Eleanor;
Kruusmägi, Martin

Publication type:

Article

CES1P1 variant −816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.

Published in:

European Journal of Clinical Pharmacology, 2016, v. 72, n. 6, p. 681, doi. 10.1007/s00228-016-2029-x

By:

Zhu, Hao-Jie;
Langaee, Taimour;
Gong, Yan;
Wang, Xinwen;
Pepine, Carl;
Cooper-DeHoff, Rhonda;
Johnson, Julie;
Markowitz, John

Publication type:

Article

Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.

Published in:

2013

By:

Suzaki, Yuki;
Uemura, Naoto;
Hosokawa, Masakiyo;
Ohashi, Kyoichi

Publication type:

Letter

Lack of a pharmacokinetic interaction between steady-state tipranavir/ritonavir and single-dose valacyclovir in healthy volunteers.

Published in:

European Journal of Clinical Pharmacology, 2011, v. 67, n. 3, p. 277, doi. 10.1007/s00228-010-0907-1

By:

Sabo, John;
Cong, Xiuyu (Julie);
Kraft, Michael-Friedrich;
Wallace, Lacey;
Castles, Mark;
Mauss, Stefan;
MacGregor, Thomas

Publication type:

Article

Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level.

Published in:

European Journal of Clinical Pharmacology, 2011, v. 67, n. 2, p. 129, doi. 10.1007/s00228-010-0916-0

By:

Kim, Kyoung-Ah;
Joo, Hyun-Jin;
Park, Ji-Young

Publication type:

Article

Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation.

Published in:

Amino Acids, 2018, v. 50, n. 8, p. 1131, doi. 10.1007/s00726-018-2590-y

By:

Chayrov, Radoslav L.;
Stylos, Evgenios K.;
Chatziathanasiadou, Maria V.;
Chuchkov, Kiril N.;
Tencheva, Aleksandra I.;
Kostagianni, Androniki D.;
Milkova, Tsenka S.;
Angelova, Assia L.;
Galabov, Angel S.;
Shishkov, Stoyan A.;
Todorov, Daniel G.;
Tzakos, Andreas G.;
Stankova, Ivanka G.

Publication type:

Article

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases.

Published in:

Amino Acids, 2014, v. 46, n. 10, p. 2435, doi. 10.1007/s00726-014-1800-5

By:

Hoque, Md.;
Islam, Md.;
Kato, Tamaki;
Nishino, Norikazu;
Ito, Akihiro;
Yoshida, Minoru

Publication type:

Article

Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2 S,3 R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl- bis-pivaloyloxymethyl (POM) prodrug form.

Published in:

Amino Acids, 2013, v. 45, n. 5, p. 1143, doi. 10.1007/s00726-013-1567-0

By:

Qian, Wen-Jian;
Burke, Terrence

Publication type:

Article

Targeted delivery of a phosphopeptide prodrug inhibits the proliferation of a human glioma cell line.

Published in:

Amino Acids, 2013, v. 45, n. 5, p. 1149, doi. 10.1007/s00726-013-1570-5

By:

Kim, Sung-min;
Yoon, Sun;
Yim, Min;
Cho, Gyunggoo;
Ryu, Eun

Publication type:

Article

Cyclic tetrapeptides with -SS- bridging between amino acid side chains for potent histone deacetylases' inhibition.

Published in:

Amino Acids, 2013, v. 45, n. 4, p. 835, doi. 10.1007/s00726-013-1527-8

By:

Arai, Toru;
Ashraful Hoque, Md.;
Nishino, Norikazu;
Kim, Hyun-Jung;
Ito, Akihiro;
Yoshida, Minoru

Publication type:

Article

Antibacterial activity of oregano essential oils against Streptococcus mutans in vitro and analysis of active components.

Published in:

BMC Complementary Medicine & Therapies, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12906-023-03890-4

By:

Yuan, Yue;
Sun, Jinlong;
Song, Yang;
Raka, Rifat Nowshin;
Xiang, Jie;
Wu, Hua;
Xiao, Junsong;
Jin, Jianming;
Hui, XiuLi

Publication type:

Article

Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics.

Published in:

Regenerative Biomaterials, 2020, v. 7, n. 2, p. 171, doi. 10.1093/rb/rbz035

By:

Xu, Hong;
Ma, Boxuan;
Jiang, Jizhou;
Xiao, Sutong;
Peng, Rongrong;
Zhuang, Weihua;
Li, Gaocan;
Wang, Yunbing

Publication type:

Article

Advances in the Development of Prodrugs as Selective Modulators of Estrogen Receptors.

Published in:

Journal of the Endocrine Society, 2022, v. 6, n. 12, p. 1, doi. 10.1210/jendso/bvac158

By:

Pollock, Julie A;
Parker, Hannah K

Publication type:

Article

Design and preparation of pH-sensitive cytotoxic liposomal formulations containing antitumor colchicine analogues for target release.

Published in:

Journal of Liposome Research, 2024, v. 34, n. 3, p. 399, doi. 10.1080/08982104.2023.2274428

By:

Shchegravina, Ekaterina S.;
Tretiakova, Daria S.;
Sitdikova, Alsu R.;
Usova, Sofia D.;
Boldyrev, Ivan A.;
Alekseeva, Anna S.;
Svirshchevskaya, Elena V.;
Vodovozova, Elena L.;
Fedorov, Alexey Yu.

Publication type:

Article

Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification.

Published in:

Journal of Liposome Research, 2015, v. 25, n. 3, p. 232, doi. 10.3109/08982104.2014.992022

By:

Mikhalin, Alexander A.;
Evdokimov, Nikolai M.;
Frolova, Liliya V.;
Magedov, Igor V.;
Kornienko, Alexander;
Johnston, Robert;
Rogelj, Snezna;
Tartis, Michaelann S.

Publication type:

Article

In vitro confirmation of the quantitative differentiation of liposomal encapsulated and non-encapsulated prednisolone (phosphate) tissue concentrations by murine phosphatases.

Published in:

Journal of Liposome Research, 2014, v. 24, n. 2, p. 130, doi. 10.3109/08982104.2013.850593

By:

Smits, Evelien A. W.;
Soetekouw, José A.;
Vromans, Herman

Publication type:

Article

Effects of liposomal encapsulation on the antioxidant activity of lipophilic prodrugs of idebenone.

Published in:

Journal of Liposome Research, 2011, v. 21, n. 1, p. 46, doi. 10.3109/08982101003735996

By:

Pignatello, Rosario;
Acquaviva, Rosaria;
Campisi, Agata;
Raciti, Giuseppina;
Musumeci, Teresa;
Puglisi, Giovanni

Publication type:

Article

Potential dopamine prodrug-loaded liposomes: preparation, characterization, and in vitro stability studies.

Published in:

Journal of Liposome Research, 2010, v. 20, n. 3, p. 250, doi. 10.3109/08982100903384129

By:

Carafa, Maria;
Marianecci, Carlotta;
Marzio, Luisa Di;
Caro, Viviana De;
Giandalia, Giulia;
Giannola, Libero Italo;
Santucci, Eleonora

Publication type:

Article

Drug metabolizing enzymes-associated chemo resistance and strategies to overcome it.

Published in:

Drug Metabolism Reviews, 2019, v. 51, n. 2, p. 196, doi. 10.1080/03602532.2019.1632886

By:

Verma, Himanshu;
Singh Bahia, Malkeet;
Choudhary, Shalki;
Kumar Singh, Pankaj;
Silakari, Om

Publication type:

Article

The CYP2W1 enzyme: regulation, properties and activation of prodrugs.

Published in:

Drug Metabolism Reviews, 2016, v. 48, n. 3, p. 369, doi. 10.1080/03602532.2016.1188939

By:

Guo, Jia;
Johansson, Inger;
Mkrtchian, Souren;
Ingelman-Sundberg, Magnus

Publication type:

Article

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery.

Published in:

Drug Metabolism Reviews, 2011, v. 43, n. 3, p. 374, doi. 10.3109/03602532.2011.560606

By:

Garattini, Enrico;
Terao, Mineko

Publication type:

Article

Qualitative structure-metabolism relationships in the hydrolysis of carbamates.

Published in:

Drug Metabolism Reviews, 2010, v. 42, n. 4, p. 551, doi. 10.3109/03602531003745960

By:

Vacondio, Federica;
Silva, Claudia;
Mor, Marco;
Testa, Bernard

Publication type:

Article