Works matching DE "MOLECULAR chaperones"

Results: 5000

Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 680, doi. 10.3390/cells14100680

By:

Verde, Enza Maria;
Secco, Valentina;
Ghezzi, Andrea;
Mandrioli, Jessica;
Carra, Serena

Publication type:

Article

The Molecular Chaperone TCP1 Affects Carcinogenicity and Is a Potential Therapeutic Target for Acute Myeloid Leukemia.

Published in:

Pharmaceutics, 2025, v. 17, n. 5, p. 557, doi. 10.3390/pharmaceutics17050557

By:

Wu, Yong;
Tu, Guihui;
Yuan, Yuxia;
Liu, Jingwen;
Jiang, Qingna;
Liu, Yang;
Wu, Qiurong;
Wu, Lixian;
Chen, Yuanzhong

Publication type:

Article

Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 700, doi. 10.3390/ph18050700

By:

Eskandari, Kiarash;
Bélanger, Sara-Maude;
Lachance, Véronik;
Kourrich, Saïd

Publication type:

Article

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 898, doi. 10.1038/nsmb.3108

By:

Mainz, Andi;
Peschek, Jirka;
Stavropoulou, Maria;
Back, Katrin C;
Bardiaux, Benjamin;
Asami, Sam;
Prade, Elke;
Peters, Carsten;
Weinkauf, Sevil;
Buchner, Johannes;
Reif, Bernd

Publication type:

Article

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 795, doi. 10.1038/nsmb.3087

By:

Thoma, Johannes;
Burmann, Björn M;
Hiller, Sebastian;
Müller, Daniel J

Publication type:

Article

Structure and mechanism of the Rubisco-assembly chaperone Raf1.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 9, p. 720, doi. 10.1038/nsmb.3062

By:

Hauser, Thomas;
Bhat, Javaid Y;
Miličić, Goran;
Wendler, Petra;
Hartl, F Ulrich;
Bracher, Andreas;
Hayer-Hartl, Manajit

Publication type:

Article

MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 8, p. 587, doi. 10.1038/nsmb.3067

By:

Clément, Camille;
Almouzni, Geneviève

Publication type:

Article

Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 12, p. 1042, doi. 10.1038/nsmb.2908

By:

Zhang, Yixiao;
Ma, Chengying;
Yuan, Yi;
Zhu, Jing;
Li, Ningning;
Chen, Chu;
Wu, Shan;
Yu, Li;
Lei, Jianlin;
Gao, Ning

Publication type:

Article

The Hsp90 ensemble: coordinated Hsp90-cochaperone complexes regulate diverse cellular processes.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 12, p. 1017, doi. 10.1038/nsmb.2927

By:

Schwenkert, Serena;
Hugel, Thorsten;
Cox, Marc B

Publication type:

Article

Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 5, p. 437, doi. 10.1038/nsmb.2813

By:

Gristick, Harry B;
Rao, Meera;
Chartron, Justin W;
Rome, Michael E;
Shan, Shu-ou;
Clemons, William M

Publication type:

Article

Epigenetically induced paucity of histone H2A.Z stabilizes fission-yeast ectopic centromeres.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1397, doi. 10.1038/nsmb.2697

By:

Ogiyama, Yuki;
Ohno, Yuko;
Kubota, Yoshino;
Ishii, Kojiro

Publication type:

Article

Conformation and dynamics of the periplasmic membrane-protein-chaperone complexes OmpX-Skp and tOmpA-Skp.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 11, p. 1265, doi. 10.1038/nsmb.2677

By:

Burmann, Björn M;
Wang, Congwei;
Hiller, Sebastian

Publication type:

Article

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 8, p. 929, doi. 10.1038/nsmb.2608

By:

Li, Zhuo;
Hartl, F Ulrich;
Bracher, Andreas

Publication type:

Article

Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 843, doi. 10.1038/nsmb.2615

By:

Sandikci, Arzu;
Gloge, Felix;
Martinez, Michael;
Mayer, Matthias P;
Wade, Rebecca;
Bukau, Bernd;
Kramer, Günter

Publication type:

Article

NMR disentangles a dynamic disaggregase machinery.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 409, doi. 10.1038/nsmb.2551

By:

Saio, Tomohide;
Kalodimos, Charalampos G

Publication type:

Article

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 3, p. 326, doi. 10.1038/nsmb.2502

By:

Li, Jing;
Richter, Klaus;
Reinstein, Jochen;
Buchner, Johannes

Publication type:

Article

Histone chaperones in nucleosome assembly and human disease.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 14, doi. 10.1038/nsmb.2461

By:

Burgess, Rebecca J;
Zhang, Zhiguo

Publication type:

Article

Structural characterization of a eukaryotic chaperone-the ribosome-associated complex.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 23, doi. 10.1038/nsmb.2447

By:

Leidig, Christoph;
Bange, Gert;
Kopp, Jürgen;
Amlacher, Stefan;
Aravind, Ajay;
Wickles, Stephan;
Witte, Gregor;
Hurt, Ed;
Beckmann, Roland;
Sinning, Irmgard

Publication type:

Article

Cryo-EM structure of the mature dengue virus at 3.5-Å resolution.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 105, doi. 10.1038/nsmb.2463

By:

Zhang, Xiaokang;
Ge, Peng;
Yu, Xuekui;
Brannan, Jennifer M;
Bi, Guoqiang;
Zhang, Qinfen;
Schein, Stan;
Zhou, Z Hong

Publication type:

Article

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1347, doi. 10.1038/nsmb.2442

By:

Seyffer, Fabian;
Kummer, Eva;
Oguchi, Yuki;
Winkler, Juliane;
Kumar, Mohit;
Zahn, Regina;
Sourjik, Victor;
Bukau, Bernd;
Mogk, Axel

Publication type:

Article

Restoring order.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 267, doi. 10.1038/nsmb.2265

By:

Chen, Inês

Publication type:

Article

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 152, doi. 10.1038/nsmb.2210

By:

Malet, Hélène;
Canellas, Flavia;
Sawa, Justyna;
Yan, Jun;
Thalassinos, Konstantinos;
Ehrmann, Michael;
Clausen, Tim;
Saibil, Helen R

Publication type:

Article

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-?<sub>1?40</sub> peptide.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 1, p. 79, doi. 10.1038/nsmb.2191

By:

Narayan, Priyanka;
Orte, Angel;
Clarke, Richard W;
Bolognesi, Benedetta;
Hook, Sharon;
Ganzinger, Kristina A;
Meehan, Sarah;
Wilson, Mark R;
Dobson, Christopher M;
Klenerman, David

Publication type:

Article

Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 875, doi. 10.1038/nsmb.2090

By:

Bracher, Andreas;
Starling-Windhof, Amanda;
Hartl, F. Ulrich;
Hayer-Hartl, Manajit

Publication type:

Article

A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 622, doi. 10.1038/nsmb.2027

By:

Kusmierczyk, Andrew R.;
Kunjappu, Mary J.;
Kim, Roger Y.;
Hochstrasser, Mark

Publication type:

Article

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 4, p. 486, doi. 10.1038/nsmb.2031

By:

DiSalvo, Susanne;
Derdowski, Aaron;
Pezza, John A.;
Serio, Tricia R.

Publication type:

Article

Genetic selection designed to stabilize proteins uncovers a chaperone called Spy.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 262, doi. 10.1038/nsmb.2016

By:

Shu Quan;
Koldewey, Philipp;
Tapley, Tim;
Kirsch, Nadine;
Ruane, Karen M.;
Pfizenmaier, Jennifer;
Rong Shi;
Hofmann, Stephan;
Foit, Linda;
Ren, Guoping;
Jakob, Ursula;
Zhaohui Xu;
Cygler, Miroslaw;
Bardwell, James C. A.

Publication type:

Article

Mechanics of Hsp70 chaperones enables differential interaction with client proteins.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 345, doi. 10.1038/nsmb.2006

By:

Schlecht, Rainer;
Erbse, Annette H.;
Bukau, Bernd;
Mayer, Matthias P.

Publication type:

Article

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 61, doi. 10.1038/nsmb.1965

By:

Li, Jing;
Richter, Klaus;
Buchner, Johannes

Publication type:

Article

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 2, p. 150, doi. 10.1038/nsmb.1970

By:

Marcinowski, Moritz;
Höller, Matthias;
Feige, Matthias J.;
Baerend, Danae;
Lamb, Don C.;
Buchner, Johannes

Publication type:

Article

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 100, doi. 10.1038/nsmb.1945

By:

Koldobskaya, Yelena;
Duguid, Erica M;
Shechner, David M;
Suslov, Nikolai B;
Ye, Jingdong;
Sidhu, Sachdev S;
Bartel, David P;
Koide, Shohei;
Kossiakoff, Anthony A;
Piccirilli, Joseph A

Publication type:

Article

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 14, doi. 10.1038/nsmb.1971

By:

Muñoz, Inés G;
Yébenes, Hugo;
Zhou, Min;
Mesa, Pablo;
Serna, Marina;
Park, Ah Young;
Bragado-Nilsson, Elisabeth;
Beloso, Ana;
de Cárcer, Guillermo;
Malumbres, Marcos;
Robinson, Carol V;
Valpuesta, José M;
Montoya, Guillermo

Publication type:

Article

Solid-state NMR and SAXS studies provide a structural basis for the activation of ?B-crystallin oligomers.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1037, doi. 10.1038/nsmb.1891

By:

Jehle, Stefan;
Rajagopal, Ponni;
Bardiaux, Benjamin;
Markovic, Stefan;
Kühne, Ronald;
Stout, Joseph R;
Higman, Victoria A;
Klevit, Rachel E;
van Rossum, Barth-Jan;
Oschkinat, Hartmut

Publication type:

Article

A direct role for Hsp90 in pre-RISC formation in Drosophila.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 1024, doi. 10.1038/nsmb.1875

By:

Miyoshi, Tomohiro;
Takeuchi, Akiko;
Siomi, Haruhiko;
Siomi, Mikiko C.

Publication type:

Article

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 7, p. 837, doi. 10.1038/nsmb.1839

By:

Merdanovic, Melisa;
Mamant, Nicolette;
Meltzer, Michael;
Poepsel, Simon;
Auckenthaler, Alexandra;
Melgaard, Rie;
Hauske, Patrick;
Nagel-Steger, Luitgard;
Clarke, Anthony R;
Kaiser, Markus;
Huber, Robert;
Ehrmann, Michael

Publication type:

Article

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 6, p. 696, doi. 10.1038/nsmb.1836

By:

Jaru-Ampornpan, Peera;
Kuang Shen;
Lam, Vinh Q.;
Ali, Mona;
Doniach, Sebastian;
Jia, Tony Z.;
Shu-ou Shan

Publication type:

Article

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 159, doi. 10.1038/nsmb.1737

By:

Perez-Miller, Samantha;
Younus, Hina;
Vanam, Ram;
Che-Hong Chen;
Mochly-Rosen, Daria;
Hurley, Thomas D.

Publication type:

Article

Crystal structure of an intramolecular chaperone mediating triple–β-helix folding.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 210, doi. 10.1038/nsmb.1746

By:

Schulz, Eike C.;
Dickmanns, Achim;
Urlaub, Henning;
Schmitt, Andreas;
Mühlenhoff, Martina;
Stummeyer, Katharina;
Schwarzer, David;
Gerardy-Schahn, Rita;
Ficner, Ralf

Publication type:

Article

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1259, doi. 10.1038/nsmb.1712

By:

Bingbing Wang;
Shuqiang Li;
Qi, Hank H.;
Dipanjan Chowdhury;
Yang Shi;
Novina, Carl D.

Publication type:

Article

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1279, doi. 10.1038/nsmb.1700

By:

Tam, Stephen;
Spiess, Christoph;
Auyeung, William;
Joachimiak, Lukasz;
Chen, Bryan;
Poirier, Michelle A;
Frydman, Judith

Publication type:

Article

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 11, p. 1141, doi. 10.1038/nsmb.1682

By:

Tsutsumi, Shinji;
Mollapour, Mehdi;
Graf, Christian;
Lee, Chung-Tien;
Scroggins, Bradley T.;
Xu, Wanping;
Haslerova, Lenka;
Hessling, Martin;
Konstantinova, Anna A.;
Trepel, Jane B.;
Panaretou, Barry;
Buchner, Johannes;
Mayer, Matthias P.;
Prodromou, Chrisostomos;
Neckers, Len

Publication type:

Article

Trigger factor finds new jobs and contacts.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 10, p. 1006, doi. 10.1038/nsmb1009-1006

By:

Hoffmann, Anja;
Bukau, Bernd

Publication type:

Article

The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 7, p. 711, doi. 10.1038/nsmb.1616

By:

DeZwaan, Diane C.;
Toogun, Oyetunji A.;
Echtenkamp, Frank J.;
Freeman, Brian C.

Publication type:

Article

Converging concepts of protein folding in vitro and in vivo.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 574, doi. 10.1038/nsmb.1591

By:

Hartl, F. Ulrich;
Hayer-Hartl, Manajit

Publication type:

Article

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 589, doi. 10.1038/nsmb.1614

By:

Kramer, Günter;
Boehringer, Daniel;
Ban, Nenad;
Bukau, Bernd

Publication type:

Article

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 281, doi. 10.1038/nsmb.1557

By:

Mickler, Moritz;
Hessling, Martin;
Ratzke, Christoph;
Buchner, Johannes;
Hugel, Thorsten

Publication type:

Article

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 287, doi. 10.1038/nsmb.1565

By:

Hessling, Martin;
Richter, Klaus;
Buchner, Johannes

Publication type:

Article

Visualizing the twists and turns of a molecular chaperone.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 235, doi. 10.1038/nsmb0309-235

By:

Neckers, Len;
Tsutsumi, Shinji;
Mollapour, Mehdi

Publication type:

Article

The importance of presentation.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1234, doi. 10.1038/nsmb1208-1234

By:

Clarke, Anthony R.

Publication type:

Article

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1255, doi. 10.1038/nsmb.1515

By:

Yam, Alice Y.;
Yu Xia;
Lin, Hen-Tzu Jill;
Burlingame, Alma;
Gerstein, Mark;
Frydman, Judith

Publication type:

Article