Works matching DE "HIGH throughput screening (Drug development)"

Results: 2939

Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system.

Published in:

Toxicological Sciences, 2025, v. 205, n. 1, p. 191, doi. 10.1093/toxsci/kfaf020

By:

Parham, Fred;
Eccles, Kristin M;
Rider, Cynthia V;
Sakamuru, Srilatha;
Xia, Menghang;
Huang, Ruili;
Tice, Raymond R;
Dinse, Gregg E;
DeVito, Michael J

Publication type:

Article

High-Throughput Design of Micro-Alloyed Al-Mg-Si Alloys.

Published in:

JOM: The Journal of The Minerals, Metals & Materials Society (TMS), 2025, v. 77, n. 6, p. 4115, doi. 10.1007/s11837-025-07323-0

By:

Ye, Junfeng;
Zhao, Hongjin;
Zhang, Bing;
Li, Minghua;
Liang, Xiaoxia

Publication type:

Article

Automated patch-clamp recordings for detecting activators and inhibitors of the epithelial sodium channel (ENaC).

Published in:

Pflügers Archiv: European Journal of Physiology, 2025, v. 477, n. 6, p. 857, doi. 10.1007/s00424-025-03087-3

By:

Sure, Florian;
Rapedius, Markus;
Diakov, Alexei;
Bertog, Marko;
Obergrussberger, Alison;
Fertig, Niels;
Korbmacher, Christoph;
Ilyaskin, Alexandr V.

Publication type:

Article

Identification and Characterization of Highly Potent and Isoenzyme-Selective Inhibitors of Deiodinase Type I via a Nonradioactive High-Throughput Screening Method.

Published in:

Thyroid, 2025, v. 35, n. 5, p. 576, doi. 10.1089/thy.2025.0036

By:

Sane, Rajas;
Seyffarth, Carola;
Kleissle, Sabrina;
Neuenschwander, Martin;
von Kries, Jens Peter;
Frädrich, Caroline;
Renko, Kostja;
Wirth, Eva K.;
Köhrle, Josef

Publication type:

Article

Colorimetric determination of tyrosinase activity and high-throughput screening of inhibitors based on in-situ formation of gold nanoparticles.

Published in:

Microchimica Acta, 2025, v. 192, n. 5, p. 1, doi. 10.1007/s00604-025-07155-4

By:

Zhou, Guohua;
Liu, Zhicheng;
Huang, Yuning;
Yang, Rufei;
Guo, Xin;
Jia, Yongmei;
Liu, Peilian;
Li, Zhiguo;
Cui, Wenjuan

Publication type:

Article

Enzymatic cleavage of model lignin dimers depends on pH, enzyme, and bond type.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-88571-7

By:

Onley, Jenny R.;
Gupta, Kshitiz;
de Raad, Markus;
Bowen, Benjamin P.;
Tan, Stephen;
Yoder, Sam;
Sale, Kenneth L.;
Singh, Anup K.;
Simmons, Blake A.;
Adams, Paul D.;
Northen, Trent R.;
Deng, Kai

Publication type:

Article

Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2032, doi. 10.3390/molecules30092032

By:

Shriwas, Pratik;
Revnew, Andre;
Roo, Sarah;
Bender, Alex;
Miller, Kevin;
Hadad, Christopher M.;
Lane, Thomas R.;
Ekins, Sean;
McElroy, Craig A.

Publication type:

Article

Combining High-Throughput Screening and Machine Learning to Predict the Formation of Both Binary and Ternary Amorphous Solid Dispersion Formulations for Early Drug Discovery and Development.

Published in:

Pharmaceutical Research, 2025, v. 42, n. 4, p. 697, doi. 10.1007/s11095-025-03853-z

By:

Lu, Tianshu;
Wu, Yiyang;
Xiong, Ping;
Zhong, Hao;
Ding, Yang;
Li, Haifeng;
Ouyang, Defang

Publication type:

Article

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59658-6

By:

Ciulla, Daniel A.;
Dranchak, Patricia K.;
Aitha, Mahesh;
van Neer, Renier H. P.;
Shah, Divia;
Tharakan, Ravi;
Wilson, Kelli M.;
Wang, Yuhong;
Braisted, John C.;
Inglese, James

Publication type:

Article

High-throughput strategies for monoclonal antibody screening: advances and challenges.

Published in:

Journal of Biological Engineering, 2025, v. 19, n. 1, p. 1, doi. 10.1186/s13036-025-00513-z

By:

Wang, Xiao-Dong;
Ma, Bao-Ying;
Lai, Shi-Ying;
Cai, Xiang-Jing;
Cong, Yan-Guang;
Xu, Jun-Fa;
Zhang, Peng-Fei

Publication type:

Article

Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2024.1522794

By:

Teng, Xin;
Zhang, Tengxun;
Rao, Chitong

Publication type:

Article

Structural Insights and Drug Repurposing of FDA-Approved Molecules against Human Agmatinase in Cancer Therapy.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 6, p. 767, doi. 10.1142/S2737416524500820

By:

Khan, Zeeshan;
Ikram, Saima;
Ahmad, Jamshaid;
Ur Rehman, Irshad;
Ahsan, Hina;
Ullah, Amin;
Alshaya, Dalal Sulaiman;
Fayad, Eman;
Hassan, Hesham M.;
Eldeen, Muhammad Alaa

Publication type:

Article

Bioluminescent imaging of an oomycete pathogen empowers chemical selections and rational fungicide applications.

Published in:

Plant Methods, 2025, v. 21, n. 1, p. 1, doi. 10.1186/s13007-025-01374-9

By:

Chen, Han;
Mao, Jiana;
Fang, Yujie;
Raza, Waqas;
Li, Zhi;
Zhang, Chongyuan;
Zhu, Yingguang;
Wang, Yuanchao;
Dong, Suomeng

Publication type:

Article

Drug screening targeting TREM2-TYROBP transmembrane binding.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01229-y

By:

Cobas-Carreño, M.;
Esteban-Martos, A.;
Tomas-Gallardo, L.;
Iribarren, I.;
Gonzalez-Palma, L.;
Rivera-Ramos, A.;
Elena-Guerra, J.;
Alarcon-Martin, E.;
Ruiz, R.;
Bravo, M. J.;
Venero, J. L.;
Morató, X.;
Ruiz, A.;
Royo, J. L.

Publication type:

Article

Establishing an Efficient Electron Transfer System for P450 Enzyme OleP to Improve the Biosynthesis of Murideoxycholic Acid by Redox Partner Engineering.

Published in:

Angewandte Chemie, 2025, v. 137, n. 19, p. 1, doi. 10.1002/ange.202423209

By:

Sun, Chixiang;
Wang, Yongchao;
Hu, Baodong;
Wang, Jianan;
Zhou, Jingwen;
Li, Jianghua;
Chen, Jian;
Du, Guocheng;
Wang, Binju;
Zhao, Xinrui

Publication type:

Article

Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications.

Published in:

BioData Mining, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13040-025-00447-8

By:

Alnasser, Sulaiman Mohammed

Publication type:

Article

Clofoctol impairs the stemness of gastric cancer and induces TNF-mediated necroptosis by directly binding to RanBP2.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05723-8

By:

Liu, Yi;
Ma, Yanhui;
Zhou, Bingqian;
Bian, Bingxian;
Zhou, Yunlan;
Chen, Shiyu;
Zhang, Peng;
Shen, Lisong;
Chen, Hui

Publication type:

Article

Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma.

Published in:

Clinical Epigenetics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13148-025-01878-0

By:

Zhong, Mengya;
Pan, Guangchao;
Tan, Jinshui;
Yao, Jingwei;
Liu, Yating;
Huang, Jiewen;
Jiang, Yuelong;
Zhu, Depeng;
Zhao, Jintao;
Xu, Bing;
Zha, Jie

Publication type:

Article

High throughput computational screening and interpretable machine learning for iodine capture of metal-organic frameworks.

Published in:

NPJ Computational Materials, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41524-025-01617-2

By:

Tan, Haoyi;
Teng, Yukun;
Shan, Guangcun

Publication type:

Article

Cardiac physiological changes induced by cardiovascular drugs from different chemical classes in zebrafish mirrored in mice: A predictive tool for comprehensive risk assessment.

Published in:

Indian Journal of Pharmacology, 2025, v. 57, n. 1, p. 12, doi. 10.4103/ijp.ijp_566_24

By:

Takawale, Rohan;
Singh, Deeksha;
Nikam, Vandana S.

Publication type:

Article

Phase 0 - Microdosing strategy in clinical trials.

Published in:

Indian Journal of Pharmacology, 2008, v. 40, n. 6, p. 240, doi. 10.4103/0253-7613.45147

By:

Rani, P. Usha;
Naidu, M. U. R.

Publication type:

Article

Computer‐Aided Synthesis Planning (CASP) and Machine Learning: Optimizing Chemical Reaction Conditions.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 55, p. 1, doi. 10.1002/chem.202401626

By:

Han, Yu;
Deng, Mingjing;
Liu, Ke;
Chen, Jia;
Wang, Yuting;
Xu, Yu‐Ning;
Dian, Longyang

Publication type:

Article

Front Cover: Discovering of Atomically Precise Metal Nanoclusters by High‐Throughput Syntheses Platform (Chem. Eur. J. 53/2024).

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 53, p. 1, doi. 10.1002/chem.202485301

By:

Tang, Li;
Wang, Li;
Wang, Bin;
Pei, Yong;
Wang, Shuxin

Publication type:

Article

Empowering Protein Engineering through Recombination of Beneficial Substitutions.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 16, p. 1, doi. 10.1002/chem.202303889

By:

Wang, Xinyue;
Li, Anni;
Li, Xiujuan;
Cui, Haiyang

Publication type:

Article

Controlling the Crystallisation and Hydration State of Crystalline Porous Organic Salts.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 64, p. 1, doi. 10.1002/chem.202302420

By:

O'Shaughnessy, Megan;
Padgham, Alex C.;
Clowes, Rob;
Little, Marc A.;
Brand, Michael C.;
Qu, Hang;
Slater, Anna G.;
Cooper, Andrew I.

Publication type:

Article

Chiroptical Recognition of Carboxylates with Charge‐Neutral Double‐Stranded Zinc(II) Helicates.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 61, p. 1, doi. 10.1002/chem.202301613

By:

Kalarikkal, Malavika G.;
Drechsler, Christoph;
Tusha, Gers;
Schäfer, Lars V.;
Van Craen, David

Publication type:

Article

Combining Molecular Quantum Mechanical Modeling and Machine Learning for Accelerated Reaction Screening and Discovery.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 60, p. 1, doi. 10.1002/chem.202301957

By:

Casetti, Nicholas;
Alfonso‐Ramos, Javier E.;
Coley, Connor W.;
Stuyver, Thijs

Publication type:

Article

A Small‐Molecule Probe with a Dual Function of miRNA Inhibition and Target identification.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 3, p. 1, doi. 10.1002/chem.202202013

By:

Wang, Weishan;
Deng, Jiafang;
Zhang, Yan;
Li, Jinbo

Publication type:

Article

Cover Feature: High‐Throughput Platform for Novel Reaction Discovery (Chem. Eur. J. 50/2022).

Published in:

2022

By:

Lu, Xiao;
Luo, Zhiji;
Huang, Ruili;
Lo, Donald C.;
Huang, Wenwei

Publication type:

Abstract

High‐Throughput Platform for Novel Reaction Discovery.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 50, p. 1, doi. 10.1002/chem.202201421

By:

Lu, Xiao;
Luo, Zhiji;
Huang, Ruili;
Lo, Donald C.;
Huang, Wenwei

Publication type:

Article

Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid.

Published in:

Angewandte Chemie, 2014, v. 126, n. 1, p. 224, doi. 10.1002/ange.201308743

By:

Rafferty, Ryan J.;
Hicklin, Robert W.;
Maloof, Katherine A.;
Hergenrother, Paul J.

Publication type:

Article

Biomimetic Miniaturized Platform Able to Sustain Arrays of Liquid Droplets for High-Throughput Combinatorial Tests.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 32, p. 5096, doi. 10.1002/adfm.201400503

By:

Neto, Ana I.;
Correia, Clara R.;
Custódio, Catarina A.;
Mano, João F.

Publication type:

Article

High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 27, p. 4303, doi. 10.1002/adfm.201304106

By:

Wang, Qin;
Xia, Xiaoxia;
Huang, Wenwen;
Lin, Yinan;
Xu, Qiaobing;
Kaplan, David L.

Publication type:

Article

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase.

Published in:

Biotechnology Letters, 2021, v. 43, n. 7, p. 1467, doi. 10.1007/s10529-021-03135-9

By:

Murugayah, Shereen A.;
Evans, Gary B.;
Tyndall, Joel D. A.;
Gerth, Monica L.

Publication type:

Article

Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling.

Published in:

Biotechnology Letters, 2021, v. 43, n. 6, p. 1143, doi. 10.1007/s10529-020-03034-5

By:

Li, Juan;
Guo, Siyu;
Hua, Qiang;
Hu, Fengxian

Publication type:

Article

Assessment of Bacterial Community Composition of Anaerobic Granular Sludge in Response to Short-Term Uranium Exposure.

Published in:

Microbial Ecology, 2018, v. 76, n. 3, p. 648, doi. 10.1007/s00248-018-1152-x

By:

Zeng, Taotao;
Zhang, Shiqi;
Gao, Xiang;
Wang, Guohua;
Lens, Piet N. L.;
Xie, Shuibo

Publication type:

Article

A novel low molecular weight VEGF receptor-binding antagonist, VGA1102, inhibits the function of VEGF and in vivo tumor growth.

Published in:

Cancer Chemotherapy & Pharmacology, 2004, v. 54, n. 1, p. 16, doi. 10.1007/s00280-004-0763-8

By:

Ueda, Yasuji;
Yamagishi, Takehiro;
Samata, Kazunori;
Ikeya, Hisao;
Hirayama, Noriko;
Okazaki, Tadayasu;
Nishihara, Sumi;
Arai, Koshi;
Yamaguchi, Sachiko;
Shibuya, Masabumi;
Nakaike, Shiro;
Tanaka, Makoto

Publication type:

Article

Phage display biopanning and isolation of target-unrelated peptides: in search of nonspecific binders hidden in a combinatorial library.

Published in:

Amino Acids, 2016, v. 48, n. 12, p. 2699, doi. 10.1007/s00726-016-2329-6

By:

Bakhshinejad, Babak;
Zade, Hesam;
Shekarabi, Hosna;
Neman, Sara

Publication type:

Article

Increased thermostability of microbial transglutaminase by combination of several hot spots evolved by random and saturation mutagenesis.

Published in:

Amino Acids, 2012, v. 42, n. 2/3, p. 987, doi. 10.1007/s00726-011-1015-y

By:

Buettner, Karin;
Hertel, Thomas;
Pietzsch, Markus

Publication type:

Article

Assessment of deoxyhypusine hydroxylase as a putative, novel drug target.

Published in:

Amino Acids, 2010, v. 38, n. 2, p. 471, doi. 10.1007/s00726-009-0406-9

By:

Kerscher, B.;
Nzukou, E.;
Kaiser, A.

Publication type:

Article

CW198 acts as a genetic insulator to block enhancer-promoter interaction in plants.

Published in:

Transgenic Research, 2022, v. 31, n. 6, p. 647, doi. 10.1007/s11248-022-00326-6

By:

Jiang, Li;
Liu, Yue;
Wen, Zhifeng;
Yang, Yingjun;
Singer, Stacy D.;
Bennett, Dennis;
Xu, Wenying;
Su, Zhen;
Yu, Zhifang;
Cohn, Josh;
Luo, Xi;
Liu, Zhongchi;
Chae, Hyunsook;
Que, Qiudeng;
Liu, Zongrang

Publication type:

Article

A high-throughput dual system to screen polyphosphate kinase mutants for efficient ATP regeneration in L-theanine biocatalysis.

Published in:

Biotechnology for Biofuels & Bioproducts, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13068-023-02361-9

By:

Gao, Hui;
Li, Mengxuan;
Wang, Qing;
Liu, Tingting;
Zhang, Xian;
Yang, Taowei;
Xu, Meijuan;
Rao, Zhiming

Publication type:

Article

A high-throughput dual system to screen polyphosphate kinase mutants for efficient ATP regeneration in L-theanine biocatalysis.

Published in:

Biotechnology for Biofuels & Bioproducts, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13068-023-02361-9

By:

Gao, Hui;
Li, Mengxuan;
Wang, Qing;
Liu, Tingting;
Zhang, Xian;
Yang, Taowei;
Xu, Meijuan;
Rao, Zhiming

Publication type:

Article

Engineering sigma factors and chaperones for enhanced heterologous lipoxygenase production in Escherichia coli.

Published in:

Biotechnology for Biofuels & Bioproducts, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13068-022-02206-x

By:

Cuiping Pang;
Guoqiang Zhang;
Song Liu;
Jingwen Zhou;
Jianghua Li;
Guocheng Du

Publication type:

Article

Microfluidic screening and genomic mutation identification for enhancing cellulase production in Pichia pastoris.

Published in:

Biotechnology for Biofuels & Bioproducts, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13068-022-02150-w

By:

Yuan, Huiling;
Zhou, Ying;
Lin, Yuping;
Tu, Ran;
Guo, Yufeng;
Zhang, Yuanyuan;
Wang, Qinhong

Publication type:

Article

A high-throughput visual screening method for p-hydroxybenzoate hydroxylase to increase phenolic compounds biosynthesis.

Published in:

Biotechnology for Biofuels & Bioproducts, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13068-022-02142-w

By:

Chen, Zhenya;
Chen, Tongtong;
Yu, Shengzhu;
Huo, Yi-Xin

Publication type:

Article

A pipeline for rapidly evaluating activity and inferring mechanisms of action of prospective antifungal compounds.

Published in:

Pest Management Science, 2024, v. 80, n. 6, p. 2804, doi. 10.1002/ps.7989

By:

Kraut‐Cohen, Judith;
Frenkel, Omer;
Covo, Shay;
Marcos‐Hadad, Evgeniya;
Carmeli, Shmuel;
Belausov, Eduard;
Minz, Dror;
Cytryn, Eddie

Publication type:

Article

Physicochemical parameters for design and development of lead herbicide molecules: Is 'Lipinski's rule of 5′ appropriate for herbicide discovery?

Published in:

Pest Management Science, 2023, v. 79, n. 5, p. 1931, doi. 10.1002/ps.7367

By:

Rani, Priyanka;
Rajak, Bikash Kumar;
Singh, Durg Vijay

Publication type:

Article

Inhibition of acyl‐ACP thioesterase as site of action of the commercial herbicides cumyluron, oxaziclomefone, bromobutide, methyldymron and tebutam.

Published in:

Pest Management Science, 2022, v. 78, n. 8, p. 3620, doi. 10.1002/ps.7004

By:

Johnen, Philipp;
Zimmermann, Sophie;
Betz, Michael;
Hendriks, Janneke;
Zimmermann, Alexandra;
Marnet, Martina;
De, Inessa;
Zimmermann, Gunther;
Kibat, Christine;
Cornaciu, Irina;
Mariaule, Vincent;
Pica, Andrea;
Clavel, Damien;
Márquez, José Antonio;
Witschel, Matthias

Publication type:

Article

In search of new herbicidal inhibitors of the non-mevalonate pathway.

Published in:

Pest Management Science, 2013, v. 69, n. 5, p. 559, doi. 10.1002/ps.3479

By:

Witschel, Matthias;
Röhl, Franz;
Niggeweg, Ricarda;
Newton, Trevor

Publication type:

Article