Works matching DE "DRUG target"

Results: 5000

Combination of RNA-sequencing data analysis, network pharmacology, molecular docking techniques to investigate the mechanism of Prunella vulgaris L. in the treatment of non-small cell lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02563-7

By:

Dan, Yanggang;
Jin, Yangli;
Wang, Jing;
Wang, Lu;
Zheng, Dawei

Publication type:

Article

PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02512-4

By:

Tian, Liang;
Liu, Liyun;
Wang, Chunlou;
Kong, Yan;
Miao, Zhigang;
Yao, Qing;
Zhang, He;
Li, Yuehong

Publication type:

Article

An integrative analysis combining bioinformatics, network pharmacology and experimental methods identified key genes of EGCG targets in Nasopharyngeal Carcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02365-x

By:

Yang, Yuhang;
Luo, Wenqi;
Feng, Zhang;
Chen, Xiaoyu;
Li, Jinqing;
Zuo, Long;
Duan, Meijiao;
He, Xiaosong;
Wang, Wenhua;
He, Feng;
Liu, Fangxian

Publication type:

Article

SF3a1: A Novel Potential Tumor Biomarker or Therapeutic Target.

Published in:

Journal of Cancer, 2025, v. 16, n. 7, p. 2353, doi. 10.7150/jca.103209

By:

Xueqian Shuai;
Yaoqi Sun;
Shupeng Liu;
Zhongping Cheng

Publication type:

Article

Arachidonic acid promotes myeloid differentiation of splenic CD45- Ter119+ cells in myeloproliferative neoplasm.

Published in:

Journal of Cancer, 2025, v. 16, n. 7, p. 2289, doi. 10.7150/jca.110478

By:

Linlin Zhang;
Yi Yang;
Xiao Yu;
Guodong Li;
Peihua Zhang;
Xiaomin Ren;
Siyu Luo;
Lin Li;
Munyurangabo, Gustave;
Yachun Jia;
Lingqin Song;
Aili He;
Guangyao Kong

Publication type:

Article

RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells.

Published in:

Journal of Cancer, 2025, v. 16, n. 7, p. 2233, doi. 10.7150/jca.105120

By:

YaTao Wang;
XueSi Yang;
ZhangQuan Yang;
ZiRui Chen;
HaiFeng Jiang;
YiCong Wang;
DongYan Shen;
GuoQiang Su

Publication type:

Article

Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell.

Published in:

Bioscience Reports, 2025, v. 45, n. 4, p. 215, doi. 10.1042/BSR20241414

By:

Yichi Zhou;
Ke Wang;
Min Ren;
Jiebin Wang;
Fanglin Wang;
Bingbing Zhuang;
Lin Chen;
Zhiqiang Zhang;
Changsheng Wang

Publication type:

Article

Multiplatform molecular analyses reveal two molecular subgroups of NF2-related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities.

Published in:

Acta Neuropathologica, 2025, v. 149, n. 1, p. 1, doi. 10.1007/s00401-025-02883-6

By:

Zhao, Fu;
Teng, Xu-Fei;
Zhang, Jing;
Li, Shi-Wei;
Wang, Lei-Ming;
Zhao, Han-Guang;
Zhang, Shun;
Zhao, Chi;
Li, Peng;
Zhao, Xiao-Bin;
Song, Shu-Hui;
Liu, Pi-Nan

Publication type:

Article

Aberrant expression of CNTRL was associated with poor prognosis, immune response and progression in glioma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02531-1

By:

Mei, Xiaoping;
Qin, Deyuan;
Zou, Min;
Teng, Hongli;
Zhai, Yang

Publication type:

Article

S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.

Published in:

Biomarker Research, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40364-025-00763-5

By:

Zhao, Jiang;
Zhou, Mi;
Yang, Chengfei;
Liu, Yang-Wuyue;
Yang, Teng;
Sun, Bishao;
Li, Benyi;
Zheng, Ji;
Dai, Shuangshuang;
Yang, Zhenxing;
Wang, Xiangwei

Publication type:

Article

Cisplatin Promotes Hepatotoxicity by cGAS‐STING Mediated Innate Immune Response.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 5, p. 1283, doi. 10.1111/jgh.16926

By:

Tao, Qiongyan;
Zhou, Yimin;
Chen, Genwen;
Sun, Jianyong

Publication type:

Article

Single‐Cell Transcriptomic Analysis Reveals an Aggressive Basal‐Like Tumor Cell Subpopulation Associated With Poor Prognosis in Intrahepatic Cholangiocarcinoma.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 5, p. 1263, doi. 10.1111/jgh.16915

By:

Liao, Changyi;
Zhang, Yuting;
Yang, Jing;
Wang, Shuo;
Li, Zhijuan;
Chen, Shuling;
Xie, Yubin;
Xu, Lixia;
Peng, Sui;
Zeng, Xuezhen;
Kuang, Ming;
Xiang, Bangde;
Sun, Kaiyu;
Zhao, Xiao

Publication type:

Article

Neuro–astrocytic network in breast cancer brain metastases: Adaptive mechanisms and novel therapeutic targets.

Published in:

International Journal of Cancer, 2025, v. 157, n. 1, p. 18, doi. 10.1002/ijc.35421

By:

Huang, Tao;
Wu, Duolu;
Jiang, Lu;
Wu, Zepei;
Zhao, Yubo;
Tang, Fansong;
Mou, Zhenglin;
Pan, Caihou;
Liu, Yi;
Tong, Aiping;
Zhou, Liangxue;
Xu, Jianguo;
Wang, Yuelong

Publication type:

Article

SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma.

Published in:

Respiratory Research, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12931-025-03252-3

By:

Zhao, Lu;
Wu, Wenliang;
Chen, Gongqi;
Huang, Chunli;
Kong, Weiqiang;
Gu, Wei;
Jie, Huiru;
Yi, Lingling;
Zhen, Guohua

Publication type:

Article

Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02561-9

By:

Guo, Maomao;
Liang, Sudong;
Guan, Zhenghui;
Mao, Jingcheng;
Xu, Zhibin;
Zhao, Wenchao;
Bian, Hao;
Zhu, Jianfeng;
Wang, Jiangping;
Jin, Xin;
Xia, Yuan

Publication type:

Article

New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02550-y

By:

Xu, Jianxiong;
Gao, Chen

Publication type:

Article

A global bibliometric and visualized analysis of the status and trends of lung metastasis in breast cancer research from 2000 to 2024.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02496-1

By:

Huang, Baoyi;
Huang, Shengchao;
Yan, Zeming;
Li, Jialun;
Zhang, Yuanqi

Publication type:

Article

Inhibition of ATG5-mediated autophagy maintains PMAIP1 stability to promote cell apoptosis and suppress triple-negative breast cancer progression.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02470-x

By:

Shang, Fangjian;
Nie, Hongfeng;
Du, Liyan;
Shang, Jin;
Song, Xiangquan;
Chen, Ya;
Li, Hui;
Wang, Zhuo;
Qi, Yixin;
Zhao, Liyan

Publication type:

Article

Advances in genitourinary cancer treatment after the 2023 ESMO congress.

Published in:

Oncology in Clinical Practice (2450-1654), 2025, v. 21, n. 2, p. 111, doi. 10.5603/ocp.98295

By:

Sigorski, Dawid;
Osmola, Małgorzata;
Wilk, Michał

Publication type:

Article

The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function.

Published in:

CNS Drugs, 2025, v. 39, n. 6, p. 545, doi. 10.1007/s40263-025-01182-8

By:

Cree, Bruce A. C.;
Berger, Joseph R.;
Greenberg, Benjamin

Publication type:

Article

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.

Published in:

Bone Research, 2025, v. 13, n. 1, p. 1, doi. 10.1038/s41413-025-00422-3

By:

Ramteke, Pranay;
Watson, Bahiyah;
Toci, Mallory;
Tran, Victoria A.;
Johnston, Shira;
Tsingas, Maria;
Barve, Ruteja A.;
Mitra, Ramkrishna;
Loeser, Richard F.;
Collins, John A.;
Risbud, Makarand V.

Publication type:

Article

Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04058-2

By:

Wang, Chaonan;
Feng, Yuyao;
Liu, Xiaoyan;
Sun, Haidan;
Guo, Zhengguang;
Shao, Jiang;
Li, Kang;
Chen, Junye;
Shu, Keqiang;
Kong, Deqiang;
Wang, Jiaxian;
Li, Yiran;
Lei, Xiangling;
Li, Chen;
Liu, Bao;
Sun, Wei;
Lai, Zhichao

Publication type:

Article

The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa.

Published in:

Horticulture Plant Journal, 2025, v. 11, n. 3, p. 1326, doi. 10.1016/j.hpj.2024.05.008

By:

Kuan Sun;
Di Fan;
Yingying Peng;
Chang Liu;
Lingfei Kong;
Ting Lan;
Xianqiang Wang;
Dan Li;
Chaofeng Li;
Keming Luo

Publication type:

Article

Expression patterns, prognostic significance, and immune correlations of the TNFAIP8 family in acute myeloid leukemia: a comprehensive bioinformatics analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02511-5

By:

Zhang, Xuezhong;
Qu, Min;
Bi, Lei;
Wang, Xiaolei;
Liu, Tonggang

Publication type:

Article

Nicotine‐driven enhancement of tumor malignancy in triple‐negative breast cancer via additive regulation of CHRNA9 and IGF1R.

Published in:

Journal of Pathology, 2025, v. 266, n. 2, p. 230, doi. 10.1002/path.6423

By:

Kuo, Yung‐Che;
Chen, Chi‐Long;
Lee, Kha‐Liang;
Wang, Hsiao‐Feng;
Drew, Victor James;
Lan, Pei‐Chi;
Ho, Yuan‐Soon;
Huang, Yen‐Hua

Publication type:

Article

Drug screening targeting TREM2-TYROBP transmembrane binding.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01229-y

By:

Cobas-Carreño, M.;
Esteban-Martos, A.;
Tomas-Gallardo, L.;
Iribarren, I.;
Gonzalez-Palma, L.;
Rivera-Ramos, A.;
Elena-Guerra, J.;
Alarcon-Martin, E.;
Ruiz, R.;
Bravo, M. J.;
Venero, J. L.;
Morató, X.;
Ruiz, A.;
Royo, J. L.

Publication type:

Article

Visualizing Epigenetics: A Review of Microscopy Techniques for Investigating DNA Methylation Patterns, Chromatin Structure, and Gene Expression.

Published in:

Microscopy & Microanalysis, 2025, v. 31, n. 2, p. 1, doi. 10.1093/mam/ozaf017

By:

Thompson, Anna-Lee C;
Wopereis, Judith L M;
Tekle, Yonas I;
Katz, Laura A

Publication type:

Article

基于 CiteSpace 及 VOSviewer 的肿瘤治疗领域研究热点与趋势的可视化分析.

Published in:

Cancer Research on Prevention & Treatment, 2025, v. 52, n. 4, p. 297, doi. 10.3971/j.issn.1000-8578.2025.24.0959

By:

方宇航;
张楚楚;
隋白鹭;
王妍;
王润兮;
陈宇;
袁欣禾;
杨洪军;
张英

Publication type:

Article

Péter Ábrányi‐Balogh.

Published in:

Angewandte Chemie, 2025, v. 137, n. 19, p. 1, doi. 10.1002/ange.202505411

By:

Ábrányi‐Balogh, Péter

Publication type:

Article

The neuroinflammatory role of microRNAs in Alzheimer's disease: pathological insights to therapeutic potential.

Published in:

Molecular & Cellular Biochemistry, 2025, v. 480, n. 5, p. 2689, doi. 10.1007/s11010-024-05164-0

By:

Liu, Wenjia;
Rao, Xin;
Sun, Wen;
Chen, Xiaodong;
Yu, Liyang;
Zhang, Jiangtao;
Chen, Jiong;
Zheng, Xiaorong

Publication type:

Article

Research advances in branched-chain amino acid metabolism in tumors.

Published in:

Molecular & Cellular Biochemistry, 2025, v. 480, n. 5, p. 2707, doi. 10.1007/s11010-024-05163-1

By:

Li, Zheng;
Chen, Sainan;
Wu, Xuechao;
Liu, Fei;
Zhu, Jing;
Chen, Jiayi;
Lu, Xiaojie;
Chi, Rui

Publication type:

Article

Exploring bioactive phytoconstituents as USP21 inhibitors for therapeutic development against cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-94825-1

By:

Anwar, Saleha;
Khan, Mohd Shahnawaz;
Yadav, Dharmendra Kumar;
Shahwan, Moyad;
Shamsi, Anas

Publication type:

Article

Expanding the SLURP1 disease spectrum: from Mal de Meleda to palmoplantar keratoderma/progressive symmetric erythrokeratoderma.

Published in:

British Journal of Dermatology, 2025, v. 192, n. 5, p. 793, doi. 10.1093/bjd/ljaf059

By:

Takeichi, Takuya;
Hsu, Chao-Kai

Publication type:

Article

New Investigator Free Papers.

Published in:: International Journal of Rheumatic Diseases, 2025, v. 28, p. 1, doi. 10.1111/1756-185X.70263
Publication type:: Article

Pseudomonas aeruginosa Detection Using Conventional PCR and Quantitative Real-Time PCR Based on Species-Specific Novel Gene Targets Identified by Pangenome Analysis.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2022.820431

By:

Wang, Chufang;
Ye, Qinghua;
Jiang, Aiming;
Zhang, Jumei;
Shang, Yuting;
Li, Fan;
Zhou, Baoqing;
Xiang, Xinran;
Gu, Qihui;
Pang, Rui;
Ding, Yu;
Wu, Shi;
Chen, Moutong;
Wu, Qingping;
Wang, Juan

Publication type:

Article

Targeting angiogenesis in gastrointestinal tumors: strategies from vascular disruption to vascular normalization and promotion strategies angiogenesis strategies in GI tumor therapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1550752

By:

Li, Jiajia;
Li, Zhengrui;
Wang, Keliang

Publication type:

Article

Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1584087

By:

Kang, Ziyu;
Wang, Junlin;
Liu, Jiyan;
Du, Li;
Liu, Xiaofei

Publication type:

Article

Novel Drug Targets for the Bradyzoite Form of Toxoplasma gondii.

Published in:

Research & Reports in Tropical Medicine, 2025, v. 16, p. 25, doi. 10.2147/RRTM.S431290

By:

Ortiz, Justin Orlando;
Potter, Anna K;
Benmerzouga, Imaan

Publication type:

Article

Dissecting Causal Relationship Among Immune Cells, Plasma Metabolites and Coronary Atherosclerosis: A Mendelian Randomization Study.

Published in:

ImmunoTargets & Therapy, 2025, v. 14, p. 175, doi. 10.2147/ITT.S508042

By:

Cao, Qi;
Liu, Jiajing;
Sun, Jingyu;
Qian, Shuangshuang;
Song, Junhuai;
Zheng, Haoyang;
Wen, Jinkun;
Zheng, Bin

Publication type:

Article

The molecular impact of miR-326 in acute lymphoblastic leukemia and its cross talk with P53.

Published in:

Annals of Hematology, 2025, v. 104, n. 4, p. 2417, doi. 10.1007/s00277-024-06181-1

By:

Shafieizadegan, Saba;
Aberuyi, Narges;
Rahgozar, Soheila

Publication type:

Article

Exploring secondary extramedullary myeloma disease: a five-predictor scoring system with spotlight on double-hit cytogenetics.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04086-y

By:

Tao, Yi;
Jin, Shi-Wei;
Wang, Zhe;
Pan, Mengmeng;
Ouyang, Wanyan;
Xu, Jie;
Liu, Yuanfang;
Wang, Yan;
Zhang, Weiping;
Li, Jian;
Mi, Jian-Qing

Publication type:

Article

Mechanistic Insights into N-Oleoylethanolamide-Mediated Hepatoprotection via PPAR-α.

Published in:

Biocell, 2025, v. 49, n. 4, p. 607, doi. 10.32604/biocell.2025.061606

By:

Ivashkevich, Darya;
Ponomarenko, Arina;
Manzhulo, Igor;
Dyuizen, Inessa

Publication type:

Article

Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization.

Published in:

American Journal of Men's Health, 2025, v. 19, n. 2, p. 1, doi. 10.1177/15579883251323187

By:

Chen, Zilong;
Wang, Quan;
Zhang, Lianqin;
Qiu, Junfeng;
Zeng, Yangling;
Kuang, Hao;
Chen, Chunxiu;
Hong, Zhiming

Publication type:

Article

Oligodendroglia vulnerability in the human dorsal striatum in Parkinson's disease.

Published in:

Acta Neuropathologica, 2025, v. 149, n. 1, p. 1, doi. 10.1007/s00401-025-02884-5

By:

Barba-Reyes, Juan M.;
Harder, Lisbeth;
Marco Salas, Sergio;
Jaisa-aad, Methasit;
Muñoz-Castro, Clara;
Garma, Leonardo D.;
Rafati, Nima;
Nilsson, Mats;
Hyman, Bradley T.;
Serrano-Pozo, Alberto;
Muñoz-Manchado, Ana B.

Publication type:

Article

Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02396-4

By:

Yang, Yaoming;
Wang, Xinbao;
Wu, Liuqing;
Zhao, Shihua;
Chen, Ran;
Yu, Guoyong

Publication type:

Article

Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02476-5

By:

Cao, Jinlong;
Chen, Siyu;
Wang, Jirong;
Fan, Xinpeng;
Liu, Shanhui;
Shan, Jiaqi;
Li, Xiaoran;
Yang, Li

Publication type:

Article

Integrating genome-wide association studies and transcriptomics prioritizes drug targets for meningioma.

Published in:

Brain Communications, 2025, v. 7, n. 2, p. 1, doi. 10.1093/braincomms/fcaf053

By:

Liao, Wan-Zhe;
Wang, Jia-He;
Zhong, Hua-Jie;
Wen, Shen-Yu;
Chen, Yang;
Chen, Jia-Qi;
Zhang, Xue-Kun;
Wu, Xin-Yi;
Tan, Jia-Nuo;
Li, Kun-Yi;
Mo, Shao-Cong;
Wang, Li-Jun

Publication type:

Article

Drug repurposing a compelling cancer strategy with bottomless opportunities: Recent advancements in computational methods and molecular mechanisms.

Published in:

Indian Journal of Pharmacology, 2023, v. 55, n. 5, p. 322, doi. 10.4103/ijp.ijp_626_22

By:

Dash, Rasmita;
Yadav, Madhulika;
Biswal, Jyotirmaya;
Samanta, Shrabani;
Sharma, Tripti;
Mohapatra, Sujata

Publication type:

Article

Students' knowledge and views on pharmacogenomic education in the medical curriculum.

Published in:

Indian Journal of Pharmacology, 2021, v. 53, n. 1, p. 19, doi. 10.4103/ijp.IJP_495_19

By:

Agrawal, Manju;
Kirtania, Lopamudra;
Jha, Anuja;
Hishikar, Rajesh

Publication type:

Article

Drug targets for corona virus: A systematic review.

Published in:

Indian Journal of Pharmacology, 2020, v. 52, n. 1, p. 56, doi. 10.4103/ijp.IJP_115_20

By:

Prajapat#, Manisha;
Sarma#, Phulen;
Shekhar#, Nishant;
Avti, Pramod;
Sinha, Shweta;
Kaur, Hardeep;
Kumar, Subodh;
Bhattacharyya, Anusuya;
Kumar, Harish;
Bansal, Seema;
Medhi, Bikash

Publication type:

Article