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- Title
Selective Labeling of Peptides with o‐Carboranes via Manganese(I)‐Catalyzed C−H Activation.
- Authors
Jei, Becky Bongsuiru; Yang, Long; Ackermann, Lutz
- Abstract
A robust method for the selective labeling of peptides via manganese(I) catalysis was devised to achieve the C‐2 alkenylation of tryptophan containing peptides with 1‐ethynyl‐o‐carboranes. The manganese‐catalyzed C−H activation was accomplished with high catalytic efficiency, and featured low toxicity, high functional group tolerance and excellent E‐stereoselectivity. This approach unravels a promising tool for the assembly of o‐carborane with structurally complex peptides of relevance to applications in boron neutron capture therapy.
- Subjects
BORON-neutron capture therapy; PEPTIDES; MANGANESE
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 37, p1
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202200811