Title: Selective Labeling of Peptides with o‐Carboranes via Manganese(I)‐Catalyzed C−H Activation.
Authors: Jei, Becky Bongsuiru; Yang, Long; Ackermann, Lutz
Abstract: A robust method for the selective labeling of peptides via manganese(I) catalysis was devised to achieve the C‐2 alkenylation of tryptophan containing peptides with 1‐ethynyl‐o‐carboranes. The manganese‐catalyzed C−H activation was accomplished with high catalytic efficiency, and featured low toxicity, high functional group tolerance and excellent E‐stereoselectivity. This approach unravels a promising tool for the assembly of o‐carborane with structurally complex peptides of relevance to applications in boron neutron capture therapy.
Subjects: BORON-neutron capture therapy; PEPTIDES; MANGANESE
Publication: Chemistry - A European Journal, 2022, Vol 28, Issue 37, p1
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.202200811

Selective Labeling of Peptides with o‐Carboranes via Manganese(I)‐Catalyzed C−H Activation.

Jei, Becky Bongsuiru; Yang, Long; Ackermann, Lutz