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- Title
Engineering of Portable Smartphone Integrated with Liposome‐Encapsulated Curcumin for Onsite Visual Ratiometric Fluorescence Imaging of Hypochlorite.
- Authors
Shen, Yizhong; Zhu, Chunlei; Wei, Yunlong; Chen, Huanhuan; Wu, Zeyu; Ye, Yingwang; Han, De‐Man
- Abstract
Precisely onsite monitoring of hypochlorite (ClO−) is of great significance to guide its rational use, reducing/avoiding its potential threat toward food safety and human health. Considering ClO− could quench fluorescence of curcumin (CCM) by oxidizing the o‐methoxyphenol of CCM into benzoquinone, a portable ratiometric fluorescence sensor integrated with smartphone was designed for realizing the visual point‐of‐care testing (POCT) of ClO−. The amphiphilic phospholipid polymer was used as carrier to wrap curcumin, forming a novel liposome‐encapsulated CCM, which provided a scaffold to bind with [Ru(bpy)3]2 through electrostatic interaction, thus assembling [Ru(bpy)3]2 ‐functionalized liposome‐encapsulated CCM ([Ru(bpy)3]2 @CCM‐NPs). Further integrated with smartphone, visual imaging of [Ru(bpy)3]2 @CCM‐NPs could be achieved and the accurate onsite detection of ClO− could be realized with a detection limit of 66.31 nM and a linear range of 0.2210 to 80.0 μM. In addition, the sensor could monitor ClO− in real samples with an onsite detection time of ∼154.0 s.
- Subjects
CURCUMIN; SMARTPHONES; FLUORESCENCE; ENGINEERING; ELECTROSTATIC interaction
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 22, p1
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202200263