This Review explores the synthesis, characterization, functionalization and biomedical applications of calcium phosphate nanoparticles from the literature. Calcium phosphate, drug delivery, gene therapy, nanomedicine, nanoparticles Keywords: calcium phosphate; drug delivery; gene therapy; nanomedicine; nanoparticles EN calcium phosphate drug delivery gene therapy nanomedicine nanoparticles 1 1 1 05/17/21 20210512 NES 210512 B Among inorganic materials b , calcium phosphate nanoparticles are well suited to transport organic or biological molecules into cells and tissue.