Similarly, cross-coupling catalysts sometimes have a "choice" between two different electrophiles, and a catalyst's selectivity for one electrophile over the other is often influenced by the ligands that it bears. Keywords: chemoselectivity; cross-coupling; reaction mechanisms; nickel; palladium EN chemoselectivity cross-coupling reaction mechanisms nickel palladium 1 1 1 04/09/21 20210407 NES 210407 B A bobcat ponders which path he should take up the mountain b : a long hiking trail or a more direct, but steep, climbing route. Chemoselectivity, cross-coupling, reaction mechanisms, nickel, palladium.