Efficient Photocatalytic Carbonyl Alkylative Amination Enabled by Titanium‐Dioxide‐Mediated Decarboxylation.

Xu, Mei; Hua, Ying; Fu, Xin; Liu, Jie

Herein, a heterogeneous carbonyl alkylative amination reaction that proceeds by photoredox catalysis has been developed. The use of nano titanium dioxide (TiO2, 25 nm) as photocatalyst allows efficient synthesis of diverse amines in good to excellent yields. Mechanistic studies reveal a single‐electron‐transfer mechanism involving the photoexcitation of TiO2 to generate alkyl radicals from carboxylic acids decarboxylation. This protocol highlights the utility of using heterogeneous semiconductor photocatalysts to promote a practical and general synthesis of complex amines from readily available feedstocks.

DECARBOXYLATION; AMINATION; ALKYL radicals; TITANIUM dioxide; CARBOXYLIC acids; AMINES

Chemistry - A European Journal, 2022, Vol 28, Issue 15, p1

0947-6539

Academic Journal

10.1002/chem.202104394