We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions.
- Authors
Empel, Claire; Jana, Sripati; Langletz, Tim; Koenigs, Rene M.
- Abstract
In this combined computational and experimental study, the C−H functionalization of 2‐phenyl pyridine with diazoalkanes was investigated. Initial evaluation by computational methods allowed the evaluation of different metal catalysts and diazoalkanes and their compatibility in this C−H functionalization reaction. With these findings, suitable reaction conditions for the C−H methylation reactions were quickly identified by using highly reactive TMS diazomethane and C−H alkylation reactions with donor/acceptor diazoalkanes, which is applied to a broad scope on alkylation reactions of 2‐aryl pyridines with TMS diazomethane and donor/acceptor diazoalkane (51 examples, up to 98 % yield).
- Subjects
METHYLATION; DIAZOALKANES; DIAZOMETHANE; METAL catalysts; EVALUATION methodology; CATALYSTS
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 12, p1
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202104321