Title: Rhoda‐Electrocatalyzed C−H Methylation and Paired Electrocatalyzed C−H Ethylation and Propylation.
Authors: Kuciński, Krzysztof; Simon, Hendrik; Ackermann, Lutz
Abstract: The use of electricity over traditional stoichiometric oxidants is a promising strategy for sustainable molecular assembly. Herein, we describe the rhoda‐electrocatalyzed C−H activation/alkylation of several N‐heteroarenes. This catalytic approach has been successfully applied to several arenes, including biologically relevant purines, diazepam, and amino acids. The versatile C−H alkylation featured water as a co‐solvent and user‐friendly trifluoroborates as alkylating agents. Finally, the rhoda‐electrocatalysis with unsaturated organotrifluoroborates proceeded by paired electrolysis.
Subjects: ETHYLATION; ALKYLATING agents; METHYLATION; ELECTRIC power consumption; ELECTROLYSIS
Publication: Chemistry - A European Journal, 2022, Vol 28, Issue 1, p1
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.202103837

Rhoda‐Electrocatalyzed C−H Methylation and Paired Electrocatalyzed C−H Ethylation and Propylation.

Kuciński, Krzysztof; Simon, Hendrik; Ackermann, Lutz