We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
One‐Pot Direct Oxidation of Primary Amines to Carboxylic Acids through Tandem ortho‐Naphthoquinone‐Catalyzed and TBHP‐Promoted Oxidation Sequence.
- Authors
Si, Tengda; Kim, Hun Young; Oh, Kyungsoo
- Abstract
Biomimetic oxidation of primary amines to carboxylic acids has been developed where the copper‐containing amine oxidase (CuAO)‐like o‐NQ‐catalyzed aerobic oxidation was combined with the aldehyde dehydrogenase (ALDH)‐like TBHP‐mediated imine oxidation protocol. Notably, the current tandem oxidation strategy provides a new mechanistic insight into the imine intermediate and the seemingly simple TBHP‐mediated oxidation pathways of imines. The developed metal‐free amine oxidation protocol allows the use of molecular oxygen and TBHP, safe forms of oxidant that may appeal to the industrial application.
- Subjects
AMINE oxidase; CARBOXYLIC acids; ALDEHYDE dehydrogenase; AMINES; OXIDATION
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 72, p18150
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202103450