Palladium‐Catalyzed Carbonylative Four‐Component Synthesis of β‐Perfluoroalkyl Amides.

Zhang, Youcan; Geng, Hui‐Qing; Wu, Xiao‐Feng

Transition‐metal‐catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl‐containing compounds. Herein, a palladium‐catalyzed four‐component perfluoroalkylation/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various β‐perfluoroalkyl amides with good functional‐group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related molecules are compatible here as well.

AMIDES; ALKYLAMINES; HYDRAZINES; ALKENES; AMINES; PALLADIUM catalysts

Chemistry - A European Journal, 2021, Vol 27, Issue 70, p17682

0947-6539

Academic Journal

10.1002/chem.202103391