Title: Frontispiece: Reductive Aldol‐type Reactions in the Synthesis of Pharmaceuticals.
Authors: Runikhina, Sofiya; Eremin, Dmitry; Chusov, Denis
Abstract: Keywords: aldol; C-C bond formation; condensation; hydrogenation; reductive alkylation EN aldol C-C bond formation condensation hydrogenation reductive alkylation 1 1 1 11/09/21 20211105 NES 211105 The aldol-type reaction became one of the forefathers of C-C bond formation reactions. Aldol, C-C bond formation, condensation, hydrogenation, reductive alkylation This Review focuses on reductive aldol-type alkylation methods implemented to the synthesis of ten approved drug substances.
Subjects: DRUGS; ALDOLS; ALKYLATION; ASYMMETRIC synthesis; HYDROGENATION; CONDENSATION
Publication: Chemistry - A European Journal, 2021, Vol 27, Issue 62, p1
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.202101768

Frontispiece: Reductive Aldol‐type Reactions in the Synthesis of Pharmaceuticals.

Runikhina, Sofiya; Eremin, Dmitry; Chusov, Denis