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- Title
Cover Feature: Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity (Chem. Eur. J. 10/2021).
- Authors
Tseliou, Vasilis; Schilder, Don; Masman, Marcelo F.; Knaus, Tanja; Mutti, Francesco G.
- Abstract
Alcohol amination, alcohol dehydrogenases, amine dehydrogenases, biocatalysis, enzyme promiscuity Keywords: alcohol amination; alcohol dehydrogenases; amine dehydrogenases; biocatalysis; enzyme promiscuity EN alcohol amination alcohol dehydrogenases amine dehydrogenases biocatalysis enzyme promiscuity 3188 3188 1 02/17/21 20210215 NES 210215 B The catalytic promiscuity of LysEDH b - which naturally catalyzes the oxidative deamination of l-lysine at the -amino group - was harnessed to create variants that exhibited alcohol dehydrogenase (ADH) and amine dehydrogenase (AmDH) activities. The dual ADH-AmDH activity (i.e., alcohol aminase) was applied to convert benzyl alcohol to benzylamine using a single enzyme.
- Subjects
ALCOHOL dehydrogenase; AMINES; OXIDOREDUCTASES; DEHYDROGENASES; BENZYL alcohol; BIOCATALYSIS
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 10, p3188
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202004194