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- Title
Synthesis of Morpholine‐Based Analogues of (−)‐Zampanolide and Their Biological Activity.
- Authors
Bold, Christian Paul; Gut, Melanie; Schürmann, Jasmine; Lucena‐Agell, Daniel; Gertsch, Jürg; Díaz, José Fernando; Altmann, Karl‐Heinz
- Abstract
We describe the convergent synthesis of three prototypical examples of a new class of analogues of the complex, cytotoxic marine macrolide (−)‐zampanolide that incorporate an embedded N‐substituted morpholine moiety in place of the natural tetrahydropyran ring. The final construction of the macrolactone core was based on a high‐yielding intramolecular HWE olefination, while the hemiaminal‐linked side chain was elaborated through a stereoselective, BINAL‐H‐mediated addition of (Z,E)‐sorbamide to a macrocyclic aldehyde precursor. The synthesis of the common functionalized morpholine building block involved two consecutive epoxide openings with tosylamide and the product of the first opening reaction, respectively, as nucleophiles. Of the three morpholino‐zampanolides investigated, the N‐acetyl and the N‐benzoyl derivatives both exhibited nanomolar antiproliferative activity, thus being essentially equipotent with the natural product. In contrast, the activity of the N‐tosyl derivative was significantly reduced.
- Subjects
MORPHOLINE; NATURAL products; NUCLEOPHILES; STRUCTURE-activity relationships; ALDEHYDES; MOIETIES (Chemistry)
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 19, p5936
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202003996