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- Title
Esterase‐Activatable Synthetic M<sup> </sup>/Cl<sup>−</sup> Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells.
- Authors
Malla, Javid Ahmad; Sharma, Virender Kumar; Lahiri, Mayurika; Talukdar, Pinaki
- Abstract
The formation of a supramolecular synthetic M /Cl− channel in the membrane phospholipid bilayer has been reported upon activation of a methyl pivalate‐linked N1,N3‐dialkyl‐2‐hydroxyisophthalamide by esterases. The channel formation induces apoptosis in cancer cells via the intrinsic pathway. Interestingly, the supramolecular channel was also shown to disrupt autophagy in cancer cells by causing alkalization of lysosomes – a feature that has been confirmed at the cellular and protein level.
- Subjects
CANCER cells; AUTOPHAGY; LYSOSOMES; BILAYER lipid membranes; SUPRAMOLECULAR chemistry; ETIOLOGY of cancer
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 52, p11946
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.202002964