EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery.

Authors

Li, Jianwei; Janoušková, Olga; Fernandez‐Alvarez, Roberto; Mesíková, Soňa; Tošner, Zdeněk; Kereïche, Sami; Uchman, Mariusz; Matějíček, Pavel

Abstract

Boron‐rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co‐assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core‐shell polymeric nanoparticles were prepared by co‐assembly of cationic PEO‐block‐PGEA diblock copolymer with sodium closo‐dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2−nano‐ion pairing. The high [B12H12]2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod‐, worm‐ and sphere‐like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod‐like particles yielded the highest internalization capability in all tested cell lines.

Subjects

POLYMERIC nanocomposites; BORON-neutron capture therapy; BASE pairs; NANOPARTICLES; BORON; NANOCAPSULES; NANOCARRIERS; TUMOR treatment

Publication

Chemistry - A European Journal, 2020, Vol 26, Issue 63, p14283

ISSN

0947-6539

Publication type

Academic Journal

DOI

10.1002/chem.202001699

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved