Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake.

Pina, Arianna; Kadri, Malika; Arosio, Daniela; Dal Corso, Alberto; Coll, Jean‐Luc; Gennari, Cesare; Boturyn, Didier

The use of multimeric ligands is considered as a promising strategy to improve tumor targeting for diagnosis and therapy. Herein, tetrameric RGD (Arg‐Gly‐Asp) peptidomimetics were designed to target αvβ3 integrin‐expressing tumor cells. These compounds were prepared by an oxime chemoselective assembly of cyclo(DKP‐RGD) ligands and a cyclodecapeptide scaffold, which allows a tetrameric presentation. The resulting tetrameric RGD peptidomimetics were shown to improve αvβ3 integrin binding compared with the monomeric form. Interestingly, these compounds were also able to enhance tumor cell endocytosis in the same way as tetrameric RGD peptides. Altogether, the results show the potential of the tetrameric cyclo(DKP‐RGD) ligands for in vivo imaging and drug delivery.

PEPTIDOMIMETICS; INTEGRINS; TUMOR diagnosis; PEPTIDES; LIGANDS (Chemistry); ENDOCYTOSIS

Chemistry - A European Journal, 2020, Vol 26, Issue 33, p7492

0947-6539

Academic Journal

10.1002/chem.202001115