¹⁵N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging.

Skovpin, Ivan V.; Svyatova, Alexandra; Chukanov, Nikita; Chekmenev, Eduard Y.; Kovtunov, Kirill V.; Koptyug, Igor V.

Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE‐based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC‐SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.

MAGNETIC resonance imaging; NUCLEAR spin; PROTON magnetic resonance

Chemistry - A European Journal, 2019, Vol 25, Issue 55, p12694

0947-6539

Academic Journal

10.1002/chem.201902724