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- Title
Room‐Temperature, Metal‐Free, and One‐Pot Preparation of 2H‐Indazoles through a Mills Reaction and Cyclization Sequence.
- Authors
Kondo, Masaru; Takizawa, Shinobu; Jiang, Yuzhao; Sasai, Hiroaki
- Abstract
The Mills reaction and cyclization of readily available 2‐aminobenzyl alcohols and nitrosobenzenes using thionyl bromide provided 2H‐indazoles in up to 88 % yields. In the metal‐free process, acetic acid played a crucial role for the both Mills reaction and cyclization. A brominated 2H‐indazole could also be obtained through the one‐pot sequence.
- Subjects
ACETIC acid; ALCOHOL drinking; BROMIDES; PLANT capacity
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 42, p9866
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.201902242