Title: Room‐Temperature, Metal‐Free, and One‐Pot Preparation of 2H‐Indazoles through a Mills Reaction and Cyclization Sequence.
Authors: Kondo, Masaru; Takizawa, Shinobu; Jiang, Yuzhao; Sasai, Hiroaki
Abstract: The Mills reaction and cyclization of readily available 2‐aminobenzyl alcohols and nitrosobenzenes using thionyl bromide provided 2H‐indazoles in up to 88 % yields. In the metal‐free process, acetic acid played a crucial role for the both Mills reaction and cyclization. A brominated 2H‐indazole could also be obtained through the one‐pot sequence.
Subjects: ACETIC acid; ALCOHOL drinking; BROMIDES; PLANT capacity
Publication: Chemistry - A European Journal, 2019, Vol 25, Issue 42, p9866
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.201902242

Room‐Temperature, Metal‐Free, and One‐Pot Preparation of 2H‐Indazoles through a Mills Reaction and Cyclization Sequence.

Kondo, Masaru; Takizawa, Shinobu; Jiang, Yuzhao; Sasai, Hiroaki