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- Title
Gold‐Catalyzed C(sp<sup>2</sup>)−C(sp) Coupling by Alkynylation through Oxidative Addition of Bromoalkynes.
- Authors
Yang, Yangyang; Schießl, Jasmin; Zallouz, Sirine; Göker, Verena; Gross, Jürgen; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K.
- Abstract
A gold(I)‐catalyzed cascade cyclization–alkynylation of allenoates using alkynyl bromide to generate β‐alkynyl‐γ‐butenolides was investigated. Whereas alkynyl iodides afforded significant amounts of the homo‐coupling of two lactone units, alkynyl bromides led to a selective reaction, and a broad functional group tolerance was observed. Under the optimized reaction conditions, it was possible to directly synthesize a large range of β‐alkynyl‐γ‐butenolides in moderate to good yields without the need for any external oxidant.
- Subjects
OXIDATIVE addition; FUNCTIONAL groups; IODIDES; BROMIDES; GOLD
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 41, p9624
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.201902213