Title: Gold‐Catalyzed C(sp<sup>2</sup>)−C(sp) Coupling by Alkynylation through Oxidative Addition of Bromoalkynes.
Authors: Yang, Yangyang; Schießl, Jasmin; Zallouz, Sirine; Göker, Verena; Gross, Jürgen; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K.
Abstract: A gold(I)‐catalyzed cascade cyclization–alkynylation of allenoates using alkynyl bromide to generate β‐alkynyl‐γ‐butenolides was investigated. Whereas alkynyl iodides afforded significant amounts of the homo‐coupling of two lactone units, alkynyl bromides led to a selective reaction, and a broad functional group tolerance was observed. Under the optimized reaction conditions, it was possible to directly synthesize a large range of β‐alkynyl‐γ‐butenolides in moderate to good yields without the need for any external oxidant.
Subjects: OXIDATIVE addition; FUNCTIONAL groups; IODIDES; BROMIDES; GOLD
Publication: Chemistry - A European Journal, 2019, Vol 25, Issue 41, p9624
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.201902213

Gold‐Catalyzed C(sp<sup>2</sup>)−C(sp) Coupling by Alkynylation through Oxidative Addition of Bromoalkynes.

Yang, Yangyang; Schießl, Jasmin; Zallouz, Sirine; Göker, Verena; Gross, Jürgen; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K.