We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catalytic C−H/C−F Coupling of Azoles and Acyl Fluorides.
- Authors
Ogiwara, Yohei; Iino, Yurika; Sakai, Norio
- Abstract
A method for the palladium/copper‐catalyzed direct acylation of azoles with acyl fluorides is described. This study reports the first examples of acyl fluorides being used as acylation reagents in transition‐metal‐catalyzed aromatic C−H bond functionalization reactions. Depending on the reaction temperature, decarbonylative coupling may also occur. Mechanistic studies suggest that the cleavage of the aromatic C−H bond, promoted by a copper‐phosphine species, is not the rate‐limiting step of this acylation.
- Subjects
AZOLES; FLUORIDES; ACYLATION; PALLADIUM; HOMOGENEOUS catalysis
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 26, p6513
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.201901219