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- Title
The Role of Onium Salts in the Pro‐Oxidant Effect of Gold Nanoparticles in Lipophilic Environments.
- Authors
Baschieri, Andrea; Del secco, Benedetta; Zaccheroni, Nelsi; Valgimigli, Luca; Amorati, Riccardo
- Abstract
Abstract: Metal nanoparticles are reported to be toxic due to the generation of free radicals at their surface. Relatively inert thiol‐capped gold nanoparticles (AuNPs) have been reported to induce radical formation in the presence of hydroperoxides, which would conflict with their potential use as inert scaffolds for the design of novel nano‐antioxidants. With the aim of clarifying this aspect, we investigated the pro‐oxidant activity of dodecanethiol‐capped AuNPs (∼5 nm diameter), prepared through the Brust–Schiffrin synthesis, by oxygen‐uptake kinetic studies. The pro‐oxidant activity was found to be proportional to the impurities of the transfer agent tetraoctylammonium bromide (TOAB) left from the synthesis and decreased on repeated washing of the nanoparticles. Under identical settings similar batches of AuNP (∼9 nm diameter) prepared through the Ulman method without onium salts showed no pro‐oxidant behavior. The alternative onium phase‐transfer agents Oct4NBF4 (Oct=octyl), Hex4NBF4 (Hex=hexyl), and Hex4NPF6 were comparatively investigated and showed lower pro‐oxidant activity depending on the counterion (Br−>PF6−>BF4−).
- Subjects
ONIUM ions; GOLD nanoparticles; HYDROPHOBIC surfaces; HYDROPEROXIDES; FREE radicals
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 36, p9113
- ISSN
0947-6539
- Publication type
Academic Journal
- DOI
10.1002/chem.201801110