Title: BrettPhos Ligand Supported Palladium-Catalyzed CO Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides.
Authors: Rangarajan, T. M.; Singh, Rajendra; Brahma, Raju; Devi, Kavita; Singh, Rishi Pal; Singh, R. P.; Prasad, Ashok K.
Abstract: We report an unprecedented BrettPhos ligand supported Pd-catalyzed CO bond-forming reaction of activated aryl halides with primary fluoroalkyl alcohols. We demonstrate that the Phosphine ligand (BrettPhos) possesses the property of altering the mechanistic pathway of reductive elimination from nucleophile to nucleophile. The Pd/BrettPhos catalyst system facilitates the reductive elimination of the oxygen nucleophile through an electronic pathway.
Subjects: LIGANDS (Chemistry); PALLADIUM; BOND formation mechanism; ARYL bromides; CARBON suboxide; PHOSPHINE oxides
Publication: Chemistry - A European Journal, 2014, Vol 20, Issue 44, p14218
ISSN: 0947-6539
Publication type: Academic Journal
DOI: 10.1002/chem.201404121

BrettPhos Ligand Supported Palladium-Catalyzed CO Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides.

Rangarajan, T. M.; Singh, Rajendra; Brahma, Raju; Devi, Kavita; Singh, Rishi Pal; Singh, R. P.; Prasad, Ashok K.