Insights into the Evaporation Kinetics of Indomethacin Solutions.

Hellstén, S.; Han, B.; Mäkilä, E.; Niemi, H.; Salonen, J.; Lehto, V.-P.; Stelzer, T.; Louhi-Kultanen, M.; Ulrich, J.

Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100 °C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.

EVAPORATION (Chemistry); INDOMETHACIN; CRYSTALLIZATION; RAMAN effect; ETHYL acetate; MASS transfer; SULFOXIDES

Chemical Engineering & Technology, 2013, Vol 36, Issue 8, p1300

0930-7516

Academic Journal

10.1002/ceat.201200718