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Title: Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant.
Authors: Tseliou, Vasilis; Knaus, Tanja; Vilím, Jan; Masman, Marcelo F.; Mutti, Francesco G.
Abstract: A NADH‐dependent engineered amine dehydrogenase from Geobacillus stearothermophilus (LE‐AmDH‐v1) was applied together with a NADH‐oxidase from Streptococcus mutans (NOx) for the kinetic resolution of pharmaceutically relevant racemic α‐chiral primary amines. The reaction conditions (e. g. pH, temperature, type of buffer) were optimised to yield S‐configured amines with up to >99 % ee.
Subjects: KINETIC resolution; GEOBACILLUS stearothermophilus; AMINES; STREPTOCOCCUS mutans
Publication: ChemCatChem, 2020, Vol 12, Issue 8, p2184
ISSN: 1867-3880
Publication type: Academic Journal
DOI: 10.1002/cctc.201902085

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Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant.